PEG300
(Synonyms: Polyethylene glycol 300)
210 Cited Publications
Revisión del cliente
Based on 210 publication(s) in Google Scholar
PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 25322-68-3
- Peso molecular:300.00
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) PEG300
More- Signal Transduct Target Ther. 2025 Dec 24;10(1):417. [Abstract]
- Signal Transduct Target Ther. 2023 Sep 25;8(1):366. [Abstract]
- Nature. 2026 May;653(8113):254-264. [Abstract]
- Nature. 2026 Jan;649(8096):477-486. [Abstract]
- Science. 2025 Nov 13;390(6774):eadq1177. [Abstract]
- Cancer Cell. 2025 Aug 12:S1535-6108(25)00330-7. [Abstract]
- Cell. 2026 Apr 27:S0092-8674(26)00388-0. [Abstract]
- Cell. 2021 Sep 2;184(18):4753-4771.e27. [Abstract]
- Mol Cancer. 2024 Apr 27;23(1):85. [Abstract]
- J Hepatol. 2023 Apr;78(4):754-769. [Abstract]
- Cell Metab. 2026 May 5;38(5):909-928.e8. [Abstract]
- Immunity. 2025 Nov 11;58(11):2864-2877.e9. [Abstract]
- Nat Metab. 2026 Jan;8(1):139-158. [Abstract]
- Nat Metab. 2025 Oct 21. [Abstract]
- Nat Aging. 2025 Mar;5(3):468-485. [Abstract]
- Nat Microbiol. 2023 Jan;8(1):121-134. [Abstract]
- Cancer Res. 2021 Apr 1;81(7):1813-1826. [Abstract]
- Nat Commun. 2025 Jan 3;16(1):289. [Abstract]
- Nat Commun. 2024 Jan 4;15(1):252. [Abstract]
- Nat Commun. 2023 May 19;14(1):2859. [Abstract]
- Nat Commun. 2023 May 24;14(1):2994. [Abstract]
- Nat Commun. 2021 May 10;12(1):2587. [Abstract]
- Hemasphere. 2026 Jun 15;10(6):e70383. [Abstract]
- Autophagy. 2026 May 25:1-21. [Abstract]
- Autophagy. 2026 May;22(5):1021-1043. [Abstract]
- Adv Sci (Weinh). 2026 Apr 27:e23716. [Abstract]
- Adv Sci (Weinh). 2026 Jan 25:e11482. [Abstract]
- Adv Sci (Weinh). 2024 Jul;11(26):e2306348. [Abstract]
- Nat Chem Biol. 2025 Sep 15. [Abstract]
- J Clin Invest. 2024 Jun 17;134(12):e177172. [Abstract]
- Theranostics. 2024 Aug 26;14(14):5429-5442. [Abstract]
- Chem Eng J. 2025 Oct 15.
- Biomaterials. 2026 Aug:331:124126. [Abstract]
- Sci Adv. 2025 Oct 31;11(44):eaea1212. [Abstract]
- Sci Adv. 2025 Sep 26;11(39):eadq7665. [Abstract]
- Sci Adv. 2025 Aug 15;11(33):eadx6587. [Abstract]
- Int J Oral Sci. 2024 Jun 18;16(1):46. [Abstract]
- J Biomed Sci. 2025 Mar 17;32(1):36. [Abstract]
- Redox Biol. 2025 Dec:88:103939. [Abstract]
- Redox Biol. 2025 May 8:84:103657. [Abstract]
- Biomark Res. 2023 Jan 24;11(1):8. [Abstract]
- MedComm (2020). 2026 Jan 13;7(1):e70548. [Abstract]
- MedComm. 2024 Apr 13;5(4):e537. [Abstract]
- Cell Rep Med. 2026 Jun 16;7(6):102833. [Abstract]
- Clin Cancer Res. 2025 Nov 13. [Abstract]
- J Neuroinflammation. 2024 Nov 14;21(1):295. [Abstract]
- Environ Int. 2026 Feb:208:110128. [Abstract]
- Adv Healthc Mater. 2025 Jun 5:e2501642. [Abstract]
- Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2536989123. [Abstract]
- Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2203480119. [Abstract]
- Cell Commun Signal. 2026 Jun 23;24(1):370. [Abstract]
- Cell Commun Signal. 2024 Jan 18;22(1):53. [Abstract]
- Int J Biol Macromol. 2025 Oct 9;330(Pt 3):148223. [Abstract]
- Acta Pharmacol Sin. 2025 Aug 19. [Abstract]
- Phytomedicine. 2026 Apr:153:157937. [Abstract]
- Phytomedicine. 2025 Oct 13:148:157385. [Abstract]
- Phytomedicine. 2024 Jun:128:155425. [Abstract]
- Free Radic Biol Med. 2026 Mar 16:246:35-50. [Abstract]
- Free Radic Biol Med. 2025 Nov:239:116-129. [Abstract]
- Free Radic Biol Med. 2025 Feb 16:228:207-220. [Abstract]
- Free Radic Biol Med. 2024 Aug 1:220:15-27. [Abstract]
- Apoptosis. 2026 Apr 29;31(5):132. [Abstract]
- Apoptosis. 2026 Jan 10;31(1):30. [Abstract]
- Br J Pharmacol. 2024 Dec 3. [Abstract]
- Brain Behav Immun. 2025 Oct 23:131:106148. [Abstract]
- Alzheimers Res Ther. 2025 Feb 14;17(1):43. [Abstract]
- Eur J Nucl Med Mol Imaging. 2024 Nov;51(13):4099-4110. [Abstract]
- Biomed Pharmacother. 2024 Feb:171:116194. [Abstract]
- Biomed Pharmacother. 2023 Jan:157:114030. [Abstract]
- Biomed Pharmacother. 2022 Nov:155:113669. [Abstract]
- Stem Cell Res Ther. 2023 Dec 20;14(1):333. [Abstract]
- Cell Chem Biol. 2025 Jul 17;32(7):926-941.e23. [Abstract]
- Aging Cell. 2023 Aug;22(8):e13896. [Abstract]
- Cell Death Discov. 2026 May 25. [Abstract]
- Cell Death Discov. 2025 Oct 6;11(1):445. [Abstract]
- Cell Rep. 2025 Sep 19;44(10):116326. [Abstract]
- Cell Rep. 2025 Jun 17;44(6):115843. [Abstract]
- Cell Rep. 2025 Jun 24;44(6):115834. [Abstract]
- Cell Rep. 2025 Apr 5;44(4):115541. [Abstract]
- Cell Rep. 2025 Apr 17;44(5):115605. [Abstract]
- Cell Rep. 2024 Dec 17;44(1):115072. [Abstract]
- Cell Rep. 2023 Apr 20;42(5):112424. [Abstract]
- Cell Rep. 2023 Mar 30;42(4):112314. [Abstract]
- Br J Cancer. 2026 May 18. [Abstract]
- Neural Regen Res. 2023 Aug;18(8):1818-1826. [Abstract]
- Antioxidants (Basel). 2026 May 18;15(5):639. [Abstract]
- J Agric Food Chem. 2026 Mar 4;74(8):7125-7138. [Abstract]
- Cell Mol Life Sci. 2026 Jan 7;83(1):60. [Abstract]
- J Agric Food Res. 2025 Oct 27;24:102486.
- Antioxid Redox Signal. 2025 Dec 26. [Abstract]
- Hepatol Int. 2024 Jun;18(3):1040-1052. [Abstract]
- Neurosci Bull. 2023 Dec;39(12):1775-1788. [Abstract]
- Neurobiol Dis. 2023 Jun 1:181:106103. [Abstract]
- Am J Chin Med. 2026;54(4):1281-1307. [Abstract]
- J Ethnopharmacol. 2026 Apr 6:360:121174. [Abstract]
- J Ethnopharmacol. 2024 Dec 23:119243. [Abstract]
- J Ethnopharmacol. 2021 Jun 28:274:114078. [Abstract]
- Food Funct. 2021 Feb 15;12(3):1207-1218. [Abstract]
- Cells. 2024 Dec 6;13(23):2016. [Abstract]
- Liver Int. 2024 Mar;44(3):691-705. [Abstract]
- Commun Biol. 2026 May 28. [Abstract]
- Life Sci. 2025 May 21:123753. [Abstract]
- Life Sci. 2025 Apr 1:366-367:123476. [Abstract]
- Life Sci. 2024 Sep 16:123061. [Abstract]
- Foods. 2024 Apr 26;13(9):1336. [Abstract]
- Int J Mol Sci. 2026 Apr 9;27(8):3381. [Abstract]
- Int J Mol Sci. 2023 Jun 9;24(12):9954. [Abstract]
- Biomolecules. 2024 Jun 19;14(6):726. [Abstract]
- Pharmaceuticals (Basel). 2023 Feb 17;16(2):316. [Abstract]
- Front Pharmacol. 2021 Sep 13:12:733420. [Abstract]
- Eur J Pharmacol. 2026 Jun 11:1030:178974. [Abstract]
- Int Immunopharmacol. 2026 Jun 30:186:117067. [Abstract]
- Eur J Pharmacol. 2025 Dec 23:1013:178508. [Abstract]
- Int Immunopharmacol. 2026 Jan 1;168(Pt 2):115892. [Abstract]
- J Mol Struct. 2025 Oct 11;1351:144356.
- Int Immunopharmacol. 2025 Apr 16:152:114428. [Abstract]
- Int Immunopharmacol. 2025 Jan 18:148:114086. [Abstract]
- Eur J Pharmacol. 2025 Feb 1:177329. [Abstract]
- Eur J Pharmacol. 2025 Feb 6:177359. [Abstract]
- Int Immunopharmacol. 2024 Sep 23;142(Pt B):113244. [Abstract]
- Int Immunopharmacol. 2024 Jun 25:138:112533. [Abstract]
- Int Immunopharmacol. 2024 Mar 30:130:111680. [Abstract]
- Eur J Pharmacol. 2024 Jan 5:962:176171. [Abstract]
- Int Immunopharmacol. 2023 Jan:114:109607. [Abstract]
- Int Immunopharmacol. 2022 Sep:110:109000. [Abstract]
- Neuropharmacology. 2026 Aug 1:293:110965. [Abstract]
- Hepatol Commun. 2026 Apr 24;10(5):e0928.
- J Med Virol. 2025 Sep;97(9):e70601. [Abstract]
- Mol Neurobiol. 2024 May;61(5):2949-2963. [Abstract]
- BMC Microbiol. 2026 Jun 9. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Sep 2;1872(1):168030. [Abstract]
- Mediators Inflamm. 2025 Feb 13:2025:7942947. [Abstract]
- FASEB J. 2024 Nov 30;38(22):e70154. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Jun 9:167288. [Abstract]
- J Cell Mol Med. 2021 Jun;25(12):5782-5798. [Abstract]
- J Inflamm Res. 2025 Nov 19:18:16231-16245. [Abstract]
- J Inflamm Res. 2025 Oct 10:18:14113-14129. [Abstract]
- iScience. 2022 Aug 13;25(9):104936. [Abstract]
- iScience. 2022 Apr 18;25(5):104267. [Abstract]
- Pestic Biochem Physiol. 2023 Dec:197:105647. [Abstract]
- J Neurochem. 2021 Sep;158(5):1110-1130. [Abstract]
- Sci Rep. 2026 Apr 18;16(1):17992. [Abstract]
- Sci Rep. 2025 Oct 16;15(1):36270. [Abstract]
- Sci Rep. 2024 Apr 8;14(1):8241. [Abstract]
- Int J Obes. 2023 Apr;47(4):325-334. [Abstract]
- Brain Res Bull. 2025 Oct 3:232:111568. [Abstract]
- Cell Signal. 2025 Aug 21:112066. [Abstract]
- Am J Pathol. 2024 Nov;194(11):2007-2022. [Abstract]
- Heliyon. 2024 Jan 18;10(3):e24988. [Abstract]
- Bone. 2023 Mar:168:116648. [Abstract]
- Animal Model Exp Med. 2026 Jun 12. [Abstract]
- Toxicol Appl Pharmacol. 2026 Jun 15:514:117911. [Abstract]
- Toxicol Appl Pharmacol. 2025 Dec 8:507:117682. [Abstract]
- Dis Model Mech. 2024 Oct 1;17(10):dmm050900. [Abstract]
- J Cancer. 2024 Jun 11;15(13):4406-4416. [Abstract]
- Front Biosci (Landmark Ed). 2026 May 22;31(5):49658. [Abstract]
- Biol Reprod. 2026 Jan 19:ioag014. [Abstract]
- Immunopharmacol Immunotoxicol. 2025 Oct;47(5):716-726. [Abstract]
- Arch Biochem Biophys. 2025 Jan 21:765:110316. [Abstract]
- Mol Immunol. 2023 May:157:176-185. [Abstract]
- Arch Biochem Biophys. 2022 Sep 30:727:109325. [Abstract]
- J Reprod Immunol. 2025 Jul 27:171:104630. [Abstract]
- Acta Diabetol. 2025 May 12. [Abstract]
- Discov Oncol. 2025 May 8;16(1):690. [Abstract]
- Front Cardiovasc Med. 2022 Jun 2;9:907747. [Abstract]
- Vet Microbiol. 2025 Dec 2:312:110827. [Abstract]
- J Integr Neurosci. 2025 Aug 22;24(8):39286. [Abstract]
- Exp Eye Res. 2025 Oct:259:110509. [Abstract]
- J Integr Neurosci. 2025 Jun 19;24(6):37182. [Abstract]
- PLoS One. 2026 Jun 12;21(6):e0351107. [Abstract]
- PLoS One. 2025 Jun 27;20(6):e0326687. [Abstract]
- Addict Biol. 2024 Mar;29(3):e13382. [Abstract]
- Clin Exp Pharmacol Physiol. 2026 Feb;53(2):e70106. [Abstract]
- Dig Dis Sci. 2025 Jun 24. [Abstract]
- Placenta. 2025 May 2:164:21-30. [Abstract]
- Mol Imaging Biol. 2022 Dec;24(6):959-972. [Abstract]
- J Pain Res. 2021 Oct 18;14:3289-3299. [Abstract]
- PeerJ. 2024 Nov 15:12:e18507. [Abstract]
- FEBS Open Bio. 2022 Oct;12(10):1761-1770. [Abstract]
- Epilepsy Res. 2023 Jul:193:107161. [Abstract]
- J Cardiothorac Surg. 2024 May 10;19(1):283. [Abstract]
- Transplant Proc. 2025 Aug 11:S0041-1345(25)00350-1. [Abstract]
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- SSRN. 2026 Jun 16.
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- Res Sq. 2026 Apr 16.
- bioRxiv. 2026 Mar 5:2026.03.04.708749. [Abstract]
- ArXiv. 2026 Mar 3.
- bioRxiv. 2026 Feb 12:2026.02.10.705144. [Abstract]
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- Patent. US20250319053A1.
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- bioRxiv. 2025 Mar 27:2025.03.24.645104. [Abstract]
- hLife. 2025 Jan 25.
- University of Minnesota. 2024.
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- bioRxiv. 2024 Jan 24.
- Research Square Preprint. 2023 Dec 1.
- Research Square Preprint. 2023 Sep 8.
- University of Michigan. 2023 Sep.
- Western University. 2023 Aug 22.
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- Universidad de Granada. 2023 Mar 27.
- Research Square Print. 2023 Mar 23.
- Research Square Print. 2022 Aug.
Actividad biológica
Descripciòn
In Vitro
The FDA has approved polyethylene glycol (PEG) for use as a vehicle or base in foods, cosmetics and pharmaceuticals, including injectable, topical, rectal and nasal formulations. PEG shows little toxicity, and is eliminated from the body intact by either the kidneys (for PEGs < 30 kDa) or in the faeces (for PEGs > 20 kDa). PEG lacks immunogenicity, and antibodies to PEG are generated in rabbits only if PEG is combined with highly immunogenic proteins[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. When administered orally, the highest concentration of PEG300 can reach up to 90%[4][5].
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. When administered orally, the highest concentration of PEG300 can reach up to 90%[4][5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 25322-68-3
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Appearance Liquid (Density: 1.127 g/cm3)
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Peso molecular 300.00
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Color Colorless to light yellow
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SMILES
[H]OCCO[H].[n]
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Synonyms
Polyethylene glycol 300
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (210)
All
Journal Impact Factor
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Lipocalin-2 drives brain metastatic progression through reciprocal tumor-microenvironment interactions in lung cancer. [Abstract]2025 Dec 24;10(1):417. PMID: 41436606 -
Signal Transduct Target Ther
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors. [Abstract]2023 Sep 25;8(1):366. PMID: 37743418 -
Nature
2026 May;653(8113):254-264. PMID: 42020743 -
Nature
2026 Jan;649(8096):477-486. PMID: 41193799 -
Science
2025 Nov 13;390(6774):eadq1177. PMID: 41231983 -
Cancer Cell
2025 Aug 12:S1535-6108(25)00330-7. PMID: 40829591 -
Cell
2026 Apr 27:S0092-8674(26)00388-0. PMID: 42049018 -
Cell
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. [Abstract]2021 Sep 2;184(18):4753-4771.e27. PMID: 34388391 -
Mol Cancer
2024 Apr 27;23(1):85. PMID: 38678233 -
J Hepatol
Multi-omics profiling of cholangiocytes reveals sex-specific chromatin state dynamics during hepatic cystogenesis in polycystic liver disease. [Abstract]2023 Apr;78(4):754-769. PMID: 36681161 -
Cell Metab
The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice. [Abstract]2026 May 5;38(5):909-928.e8. PMID: 41780522 -
Immunity
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors. [Abstract]2025 Nov 11;58(11):2864-2877.e9. PMID: 41175874 -
Nat Metab
Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes. [Abstract]2026 Jan;8(1):139-158. PMID: 41482566 -
Nat Metab
Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation. [Abstract]2025 Oct 21. PMID: 41120706 -
Nat Aging
2025 Mar;5(3):468-485. PMID: 39779911 -
Nat Microbiol
2023 Jan;8(1):121-134. PMID: 36604514 -
Cancer Res
Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. [Abstract]2021 Apr 1;81(7):1813-1826. PMID: 33495232 -
Nat Commun
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway. [Abstract]2025 Jan 3;16(1):289. PMID: 39753529 -
Nat Commun
Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. [Abstract]2024 Jan 4;15(1):252. PMID: 38177117 -
Nat Commun
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. [Abstract]2023 May 19;14(1):2859. PMID: 37208329 -
Nat Commun
2023 May 24;14(1):2994. PMID: 37225695 -
Nat Commun
An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli. [Abstract]2021 May 10;12(1):2587. PMID: 33972537 -
Hemasphere
CEBP and ZEB2 alterations define three distinct subtypes of B-cell acute lymphoblastic leukemia. [Abstract]2026 Jun 15;10(6):e70383. PMID: 42306066 -
Autophagy
Byakangelicin alleviates metabolic dysfunction-associated steatohepatitis by selective inhibition of a non-canonical MTORC1 signaling pathway. [Abstract]2026 May 25:1-21. PMID: 42152469 -
Autophagy
Phase separation of OPTN initiates mitophagy to orchestrate craniofacial bone mineralization. [Abstract]2026 May;22(5):1021-1043. PMID: 41692957 -
Adv Sci (Weinh)
Microglia-Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis-Associated Encephalopathy. [Abstract]2026 Apr 27:e23716. PMID: 42037180 -
Adv Sci (Weinh)
Inhibition of SLC11A1-Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke. [Abstract]2026 Jan 25:e11482. PMID: 41580979 -
Adv Sci (Weinh)
Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape. [Abstract]2024 Jul;11(26):e2306348. PMID: 38696655 -
Nat Chem Biol
2025 Sep 15. PMID: 40954224 -
J Clin Invest
Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models. [Abstract]2024 Jun 17;134(12):e177172. PMID: 38950288 -
Theranostics
2024 Aug 26;14(14):5429-5442. PMID: 39310100 -
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Biomaterials
Conjugated polymer intrachain donor-acceptor reconfiguration-tailored off-on NIR-II photoacoustic probes with ultralow background for high-fidelity imaging of immunotherapy-associated macrophage reprogramming. [Abstract]2026 Aug:331:124126. PMID: 41830766 -
Sci Adv
Tumor-derived RAC1A159V mutation promotes an immunosuppressive microenvironment that represses response to immune checkpoint inhibitor. [Abstract]2025 Oct 31;11(44):eaea1212. PMID: 41160695 -
Sci Adv
Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling. [Abstract]2025 Sep 26;11(39):eadq7665. PMID: 40991686 -
Sci Adv
2025 Aug 15;11(33):eadx6587. PMID: 40815641 -
Int J Oral Sci
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma. [Abstract]2024 Jun 18;16(1):46. PMID: 38886342 -
J Biomed Sci
Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4. [Abstract]2025 Mar 17;32(1):36. PMID: 40091020 -
Redox Biol
Melatonin attenuates atherosclerotic plaque vulnerability through SIRT6-dependent regulation of vascular smooth muscle cells senescence. [Abstract]2025 Dec:88:103939. PMID: 41308252 -
Redox Biol
Ferroptosis in acute liver Failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions. [Abstract]2025 May 8:84:103657. PMID: 40393152 -
Biomark Res
Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia. [Abstract]2023 Jan 24;11(1):8. PMID: 36691065 -
MedComm (2020)
Emestrin-Type Epidithiodiketopiperazines Inhibited Gasdermin D-Mediated Pyroptosis via Caspase-3/7 Activation. [Abstract]2026 Jan 13;7(1):e70548. PMID: 41536519 -
MedComm
2024 Apr 13;5(4):e537. PMID: 38617434 -
Cell Rep Med
Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression. [Abstract]2026 Jun 16;7(6):102833. PMID: 42173096 -
Clin Cancer Res
Ibrutinib and PD-1 blockade potentiate mesothelin-targeting CAR-T cell therapy in preclinical models of pancreatic cancer. [Abstract]2025 Nov 13. PMID: 41231131 -
J Neuroinflammation
Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss. [Abstract]2024 Nov 14;21(1):295. PMID: 39543619 -
Environ Int
Combined effects of ozone and heat on intestinal barrier integrity and epithelial renewal: mediating roles of gut microbiota and tryptophan metabolism. [Abstract]2026 Feb:208:110128. PMID: 41687337 -
Adv Healthc Mater
pH-Responsive Probiotic-Liposome Hybrid System Synergistically Treats Radiation-Induced Injury via Dual Mechanisms of Anti-Inflammatory and Microbiome Modulation. [Abstract]2025 Jun 5:e2501642. PMID: 40474448 -
Proc Natl Acad Sci U S A
Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread. [Abstract]2026 Jun 16;123(24):e2536989123. PMID: 42268890 -
Proc Natl Acad Sci U S A
Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids. [Abstract]2022 Oct 11;119(41):e2203480119. PMID: 36197994 -
Cell Commun Signal
Glucose transport dependency defines a therapeutic vulnerability in JAK2V617F-driven myeloproliferative neoplasms. [Abstract]2026 Jun 23;24(1):370. PMID: 42337564 -
Cell Commun Signal
Mitochondria-derived methylmalonic acid aggravates ischemia-reperfusion injury by activating reactive oxygen species-dependent ferroptosis. [Abstract]2024 Jan 18;22(1):53. PMID: 38238728 -
Int J Biol Macromol
The role of solute carrier family 16 member 3 protein in hepatocellular carcinoma and sorafenib resistance. [Abstract]2025 Oct 9;330(Pt 3):148223. PMID: 41075888 -
Acta Pharmacol Sin
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity. [Abstract]2025 Aug 19. PMID: 40830678 -
Phytomedicine
Cyasterone regulates lipid metabolism and autophagy mediated by the AMPK signaling pathway to improve KOA synovitis. [Abstract]2026 Apr:153:157937. PMID: 41687535 -
Phytomedicine
Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis. [Abstract]2025 Oct 13:148:157385. PMID: 41086673 -
Phytomedicine
Wogonin improves colitis by activating the AhR pathway to regulate the plasticity of ILC3/ILC1. [Abstract]2024 Jun:128:155425. PMID: 38518634 -
Free Radic Biol Med
Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer. [Abstract]2026 Mar 16:246:35-50. PMID: 41520847 -
Free Radic Biol Med
Linarin alleviates high-fat diet-induced hepatic steatosis by inhibiting PDE4D and activating the cAMP/PKA/CREB pathway. [Abstract]2025 Nov:239:116-129. PMID: 40712988 -
Free Radic Biol Med
Targeting PGAM5 attenuates airway inflammation in asthma by inhibiting HMGB1 release in bronchial epithelium. [Abstract]2025 Feb 16:228:207-220. PMID: 39756489 -
Free Radic Biol Med
The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation. [Abstract]2024 Aug 1:220:15-27. PMID: 38679301 -
Apoptosis
Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer. [Abstract]2026 Apr 29;31(5):132. PMID: 42050204 -
Apoptosis
2026 Jan 10;31(1):30. PMID: 41518439 -
Br J Pharmacol
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll-like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose-fed rats. [Abstract]2024 Dec 3. PMID: 39627019 -
Brain Behav Immun
Microglia-mediated Perineuronal nets loss contributes to social memory deficit in male mice after repeated neonatal sevoflurane exposure. [Abstract]2025 Oct 23:131:106148. PMID: 41138885 -
Alzheimers Res Ther
Pathway-based network medicine identifies novel natural products for Alzheimer's disease. [Abstract]2025 Feb 14;17(1):43. PMID: 39953559 -
Eur J Nucl Med Mol Imaging
Combining [177Lu]Lu-DOTA-TOC PRRT with PARP inhibitors to enhance treatment efficacy in small cell lung cancer. [Abstract]2024 Nov;51(13):4099-4110. PMID: 39023784 -
Biomed Pharmacother
Sakuranetin reduces inflammation and chondrocyte dysfunction in osteoarthritis by inhibiting the PI3K/AKT/NF-κB pathway. [Abstract]2024 Feb:171:116194. PMID: 38262147 -
Biomed Pharmacother
Butein suppresses PD-L1 expression via downregulating STAT1 in non-small cell lung cancer. [Abstract]2023 Jan:157:114030. PMID: 36455456 -
Biomed Pharmacother
PARP1 inhibition by Olaparib reduces the lethality of pancreatic cancer cells and increases their sensitivity to Gemcitabine. [Abstract]2022 Nov:155:113669. PMID: 36113257 -
Stem Cell Res Ther
Hypertonicity induces mitochondrial extracellular vesicles (MEVs) that activate TNF-α and β-catenin signaling to promote adipocyte dedifferentiation. [Abstract]2023 Dec 20;14(1):333. PMID: 38115136 -
Cell Chem Biol
Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity. [Abstract]2025 Jul 17;32(7):926-941.e23. PMID: 40628257 -
Aging Cell
A rationally designed fluorescence probe achieves highly specific and long-term detection of senescence in vitro and in vivo. [Abstract]2023 Aug;22(8):e13896. PMID: 37312431 -
Cell Death Discov
ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance. [Abstract]2026 May 25. PMID: 42185253 -
Cell Death Discov
Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma. [Abstract]2025 Oct 6;11(1):445. PMID: 41053160 -
Cell Rep
2025 Sep 19;44(10):116326. PMID: 40975867 -
Cell Rep
SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes. [Abstract]2025 Jun 17;44(6):115843. PMID: 40531618 -
Cell Rep
2025 Jun 24;44(6):115834. PMID: 40512624 -
Cell Rep
PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma. [Abstract]2025 Apr 5;44(4):115541. PMID: 40188436 -
Cell Rep
The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy. [Abstract]2025 Apr 17;44(5):115605. PMID: 40249707 -
Cell Rep
Pathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis. [Abstract]2024 Dec 17;44(1):115072. PMID: 39693225 -
Cell Rep
CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue. [Abstract]2023 Apr 20;42(5):112424. PMID: 37086405 -
Cell Rep
2023 Mar 30;42(4):112314. PMID: 37000627 -
Br J Cancer
Circulating tumour cell-derived xenograft as a preclinical platform for metastatic breast cancer. [Abstract]2026 May 18. PMID: 42151560 -
Neural Regen Res
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease. [Abstract]2023 Aug;18(8):1818-1826. PMID: 36751811 -
Antioxidants (Basel)
Rhamnocitrin Ameliorates the Intestinal Fibrosis in DSS-Induced Colitis Mice by Modulating Host-Metabolites and Remodeling the Gut Microbiome. [Abstract]2026 May 18;15(5):639. PMID: 42193259 -
J Agric Food Chem
Daidzein Confers Prophylactic Protection against Food Allergy by Restoring Immune Regulation, Intestinal Barrier Integrity, and Microbiota-Metabolite Homeostasis. [Abstract]2026 Mar 4;74(8):7125-7138. PMID: 41705388 -
Cell Mol Life Sci
RRx-001 ameliorates astrocyte pyroptosis by regulating LCN2-NLRP3 inflammasome activation in an MPTP-induced parkinson's disease mouse model. [Abstract]2026 Jan 7;83(1):60. PMID: 41495462 -
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Antioxid Redox Signal
Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage. [Abstract]2025 Dec 26. PMID: 41468154 -
Hepatol Int
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation. [Abstract]2024 Jun;18(3):1040-1052. PMID: 38172440 -
Neurosci Bull
Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid-β and Prevents Alzheimer's Disease-Type Pathology and Cognitive Deficits. [Abstract]2023 Dec;39(12):1775-1788. PMID: 37316674 -
Neurobiol Dis
2023 Jun 1:181:106103. PMID: 36997128 -
Am J Chin Med
Astragaloside IV Ameliorates Diabetic Kidney Disease via Inhibiting MAPK Pathway and Alleviating Metabolic Dysregulation. [Abstract]2026;54(4):1281-1307. PMID: 42289390 -
J Ethnopharmacol
A novel polysaccharide from Qamgur (Brassica rapa L.) mitigates pulmonary fibrosis by regulating inflammatory, epithelial-mesenchymal transition, and fibrotic pathways. [Abstract]2026 Apr 6:360:121174. PMID: 41500353 -
J Ethnopharmacol
San Huang Xiao Yan recipe promoted wound healing in diabetic ulcer mice by inhibiting Th17 cell differentiation. [Abstract]2024 Dec 23:119243. PMID: 39722327 -
J Ethnopharmacol
Xinyang Tablet inhibits MLK3-mediated pyroptosis to attenuate inflammation and cardiac dysfunction in pressure overload. [Abstract]2021 Jun 28:274:114078. PMID: 33798659 -
Food Funct
Resveratrol attenuates dapagliflozin-induced renal gluconeogenesis via activating the PI3K/Akt pathway and suppressing the FoxO1 pathway in type 2 diabetes. [Abstract]2021 Feb 15;12(3):1207-1218. PMID: 33432947 -
Cells
Riluzole Reverses Blood-Testis Barrier Loss to Rescue Chemotherapy-Induced Male Infertility by Binding to TRPC. [Abstract]2024 Dec 6;13(23):2016. PMID: 39682764 -
Liver Int
Ferritinophagy-mediated ferroptosis facilitates methotrexate-induced hepatotoxicity by high-mobility group box 1 (HMGB1). [Abstract]2024 Mar;44(3):691-705. PMID: 38082504 -
Commun Biol
2026 May 28. PMID: 42209711 -
Life Sci
Transcranial direct current stimulation alleviates chronic pain in knee osteoarthritis by modulating microglial and astrocytic polarization and neuroinflammation. [Abstract]2025 May 21:123753. PMID: 40409582 -
Life Sci
Oxalate stimulates macrophage secretion of prostaglandin E2 to promote renal tubular epithelial cell osteogenesis. [Abstract]2025 Apr 1:366-367:123476. PMID: 39986650 -
Life Sci
NADPH oxidase 1/4 dual inhibitor setanaxib suppresses platelet activation and thrombus formation. [Abstract]2024 Sep 16:123061. PMID: 39293714 -
Foods
Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice. [Abstract]2024 Apr 26;13(9):1336. PMID: 38731707 -
Int J Mol Sci
A Clozapine-Responsive GPCR-Based Gene Switch for Pharmacological Control of Gene Expression in Mammalian Cells and In Vivo. [Abstract]2026 Apr 9;27(8):3381. PMID: 42074026 -
Int J Mol Sci
PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice. [Abstract]2023 Jun 9;24(12):9954. PMID: 37373102 -
Biomolecules
Gasdermin D Inhibitor Necrosulfonamide Alleviates Angiotensin II-Induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice. [Abstract]2024 Jun 19;14(6):726. PMID: 38927129 -
Pharmaceuticals (Basel)
Therapeutic Effect of Costunolide in Autoimmune Hepatitis: Network Pharmacology and Experimental Validation. [Abstract]2023 Feb 17;16(2):316. PMID: 37163367 -
Front Pharmacol
2021 Sep 13:12:733420. PMID: 34594224 -
Eur J Pharmacol
Fisetin alleviates osteoporosis by promoting osteogenesis and suppressing adipogenesis via the Wnt/β-catenin signaling pathway in mice. [Abstract]2026 Jun 11:1030:178974. PMID: 42276194 -
Int Immunopharmacol
Inhibition of the Caspase-9/GSDME axis by Auranofin: a potential therapeutic strategy for bacterial toxin-mediated severe systemic disease. [Abstract]2026 Jun 30:186:117067. PMID: 42378825 -
Eur J Pharmacol
Leonurine attenuates cisplatin-induced AKI-CKD transition via Nrf2-Mediated ferroptosis suppression. [Abstract]2025 Dec 23:1013:178508. PMID: 41448263 -
Int Immunopharmacol
2026 Jan 1;168(Pt 2):115892. PMID: 41273847 -
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Int Immunopharmacol
CSF1R inhibition agents protect against cisplatin ototoxicity and synergize with immunotherapy for Head and Neck Squamous Cell Carcinoma. [Abstract]2025 Apr 16:152:114428. PMID: 40073814 -
Int Immunopharmacol
Plumbagin improves myocardial fibrosis after myocardial infarction by inhibiting the AKT/mTOR pathway to upregulate autophagy levels. [Abstract]2025 Jan 18:148:114086. PMID: 39827666 -
Eur J Pharmacol
GW4064 inhibits migration and invasion in human glioblastoma multiforme through the downregulation of PKCα. [Abstract]2025 Feb 1:177329. PMID: 39900326 -
Eur J Pharmacol
2025 Feb 6:177359. PMID: 39922422 -
Int Immunopharmacol
Simvastatin induces ferroptosis and activates anti-tumor immunity to sensitize anti-PD-1 immunotherapy in microsatellite stable gastric cancer. [Abstract]2024 Sep 23;142(Pt B):113244. PMID: 39317047 -
Int Immunopharmacol
Icaritin attenuates ischemia-reperfusion injury by anti-inflammation, anti-oxidative stress, and anti-autophagy in mouse liver. [Abstract]2024 Jun 25:138:112533. PMID: 38924868 -
Int Immunopharmacol
Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis. [Abstract]2024 Mar 30:130:111680. PMID: 38368772 -
Eur J Pharmacol
Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats. [Abstract]2024 Jan 5:962:176171. PMID: 37996009 -
Int Immunopharmacol
2023 Jan:114:109607. PMID: 36700777 -
Int Immunopharmacol
JMJD3/H3K27me3 epigenetic modification regulates Th17/Treg cell differentiation in ulcerative colitis. [Abstract]2022 Sep:110:109000. PMID: 35777266 -
Neuropharmacology
CXCL10 activates STAT3 signaling to promote ferroptosis in the spinal dorsal horn during neuropathic pain. [Abstract]2026 Aug 1:293:110965. PMID: 41951153 -
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J Med Virol
Development of a HEp2-CDX Mouse Model With Sustained High RSV Viral Loads for Robust Antiviral Therapeutic Evaluation. [Abstract]2025 Sep;97(9):e70601. PMID: 40947663 -
Mol Neurobiol
Electroacupuncture Exerts Analgesic Effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory Pain. [Abstract]2024 May;61(5):2949-2963. PMID: 37957422 -
BMC Microbiol
Pathogenic signatures and therapeutic evaluation of emergent MPXV Clade Ib in low-susceptibility and immunocompromised mouse models. [Abstract]2026 Jun 9. PMID: 42260341 -
Biochim Biophys Acta Mol Basis Dis
ClC-3 inhibition induces autophagy to reverse cisplatin resistance in cervical cancer via the Akt/mTOR pathway. [Abstract]2025 Sep 2;1872(1):168030. PMID: 40907802 -
Mediators Inflamm
Selenium Nanoparticles Decorated With Stevioside Potentially Attenuate Fructose Palmitate Induced Lipid Accumulation in HepG2 Cells. [Abstract]2025 Feb 13:2025:7942947. PMID: 39981401 -
FASEB J
METTL3 and IGF2BP2 coordinately regulate FOSL1 mRNA via m6A modification, suppressing trophoblast invasion and contributing to fetal growth restriction. [Abstract]2024 Nov 30;38(22):e70154. PMID: 39565355 -
Biochim Biophys Acta Mol Basis Dis
Effect of alternating nicotinamide phosphoribosyltransferase expression levels on mitophagy in Alzheimer's disease mouse models. [Abstract]2024 Jun 9:167288. PMID: 38862096 -
J Cell Mol Med
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression. [Abstract]2021 Jun;25(12):5782-5798. PMID: 33982381 -
J Inflamm Res
SIRT1 Enhancement is Required for the Induction of Anti-Inflammatory Effect of Micheliolide in Carbon Tetrachloride Induced Liver Fibrosis in Mice. [Abstract]2025 Nov 19:18:16231-16245. PMID: 41287768 -
J Inflamm Res
The Pomegranate Peel Polyphenols Protects Acne Vulgaris by Regulating Inflammation Through Notch/NF-κB Signal Pathway. [Abstract]2025 Oct 10:18:14113-14129. PMID: 41098683 -
iScience
Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain. [Abstract]2022 Aug 13;25(9):104936. PMID: 36072549 -
iScience
Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway. [Abstract]2022 Apr 18;25(5):104267. PMID: 35521538 -
Pestic Biochem Physiol
2-Methoxyestradiol ameliorates paraquat-induced pulmonary fibrosis by inhibiting the TGF-β1/Smad2/3 signaling pathway. [Abstract]2023 Dec:197:105647. PMID: 38072522 -
J Neurochem
Spinal Nrf2 translocation may inhibit neuronal NF-κB activation and alleviate allodynia in a rat model of bone cancer pain. [Abstract]2021 Sep;158(5):1110-1130. PMID: 34254317 -
Sci Rep
m6A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis. [Abstract]2026 Apr 18;16(1):17992. PMID: 42000779 -
Sci Rep
2025 Oct 16;15(1):36270. PMID: 41102391 -
Sci Rep
Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model. [Abstract]2024 Apr 8;14(1):8241. PMID: 38589452 -
Int J Obes
2023 Apr;47(4):325-334. PMID: 36782056 -
Brain Res Bull
ATF3 enhancement of CHAC1 expression: A pathway to neuronal ferroptosis in spinal cord injury. [Abstract]2025 Oct 3:232:111568. PMID: 41046987 -
Cell Signal
Poly-L-arginine induces asthma pyroptosis in lung epithelial cells by promoting nuclear translocation of the PKM2 dimer. [Abstract]2025 Aug 21:112066. PMID: 40848938 -
Am J Pathol
2024 Nov;194(11):2007-2022. PMID: 39168365 -
Heliyon
2024 Jan 18;10(3):e24988. PMID: 38317912 -
Bone
HIF-1α mediates osteoclast-induced disuse osteoporosis via cytoophidia in the femur of mice. [Abstract]2023 Mar:168:116648. PMID: 36563716 -
Animal Model Exp Med
Chrysin alleviates pressure overload-induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway-mediated oxidative stress response. [Abstract]2026 Jun 12. PMID: 42286832 -
Toxicol Appl Pharmacol
Aureusidin protects against osteoarthritis via Caspase-3/gasdermin E-mediated pyroptosis. [Abstract]2026 Jun 15:514:117911. PMID: 42297245 -
Toxicol Appl Pharmacol
2025 Dec 8:507:117682. PMID: 41371369 -
Dis Model Mech
Sex hormone receptors, calcium-binding protein and Yap1 signaling regulate sex-dependent liver cell proliferation following partial hepatectomy. [Abstract]2024 Oct 1;17(10):dmm050900. PMID: 39397390 -
J Cancer
Treatment of HNSC and pulmonary metastasis using the anti-helminthic drug niclosamide to modulate Stat3 signaling activity. [Abstract]2024 Jun 11;15(13):4406-4416. PMID: 38947381 -
Front Biosci (Landmark Ed)
2026 May 22;31(5):49658. PMID: 42216530 -
Biol Reprod
2026 Jan 19:ioag014. PMID: 41553274 -
Immunopharmacol Immunotoxicol
All- trans retinoic acid ameliorates S100-induced experimental autoimmune hepatitis by regulating the Treg/Th17 balance. [Abstract]2025 Oct;47(5):716-726. PMID: 40936263 -
Arch Biochem Biophys
Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles alleviates atherosclerosis by suppressing macrophage ferroptosis via the NRF2/SLC7A11/GPX4 pathway. [Abstract]2025 Jan 21:765:110316. PMID: 39848420 -
Mol Immunol
Low temperature reduces occludin expression in bronchial epithelial cells: Implications in cold-induced asthma. [Abstract]2023 May:157:176-185. PMID: 37044043 -
Arch Biochem Biophys
Oxalate induces the ossification of RTECs by activating the JAK2/STAT3 signaling pathway and participates in the formation of kidney stones. [Abstract]2022 Sep 30:727:109325. PMID: 35749806 -
J Reprod Immunol
Association of elevated ACSL4 expression with impaired endometrial receptivity in endometriosis and restoration by ACSL4 inhibitor PRGL493. [Abstract]2025 Jul 27:171:104630. PMID: 40763450 -
Acta Diabetol
Dapagliflozin ameliorates metabolic and hepatic outcomes in a mouse model of metabolic dysfunction-associated steatotic liver disease and diabetes. [Abstract]2025 May 12. PMID: 40353918 -
Discov Oncol
F-α-DDB-derivative, a novel synthetic of bifendate, plus epirubicin improves antitumor efficacy against triple negative breast cancer without additional cardiotoxicity. [Abstract]2025 May 8;16(1):690. PMID: 40338489 -
Front Cardiovasc Med
GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis. [Abstract]2022 Jun 2;9:907747. PMID: 35722096 -
Vet Microbiol
Highly virulent Aerococcus viridans activates the RIPK3 signaling pathway, inducing necroptosis and inflammation in bovine mammary epithelial cells and murine mammary tissue. [Abstract]2025 Dec 2:312:110827. PMID: 41365050 -
J Integr Neurosci
Inhibition of cGAS Reduces Brain Injury and Facilitates Neurological Recovery via the STING-Mediated Signaling Pathway After Germinal Matrix Hemorrhage in Neonatal Mice. [Abstract]2025 Aug 22;24(8):39286. PMID: 40919625 -
Exp Eye Res
2025 Oct:259:110509. PMID: 40633646 -
J Integr Neurosci
Idebenone Orchestrates Anti-Inflammatory and Antioxidant Responses to Alleviate Brain Injury After Intracerebral Hemorrhage in Mice. [Abstract]2025 Jun 19;24(6):37182. PMID: 40613371 -
PLoS One
The mTOR/Akt pathway is involved in regulating astrocyte growth and GLT-1 expression during cerebral ischemia-reperfusion. [Abstract]2026 Jun 12;21(6):e0351107. PMID: 42284260 -
PLoS One
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy. [Abstract]2025 Jun 27;20(6):e0326687. PMID: 40577270 -
Addict Biol
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Clin Exp Pharmacol Physiol
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Dig Dis Sci
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Placenta
METTL3 suppressing SLC31A1 m6A modification regulates trophoblast migration and invasion. [Abstract]2025 May 2:164:21-30. PMID: 40088504 -
Mol Imaging Biol
PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine. [Abstract]2022 Dec;24(6):959-972. PMID: 35732988 -
J Pain Res
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PeerJ
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FEBS Open Bio
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Epilepsy Res
Inhibition of mTORC2 improves brain injury in epileptic rats by promoting chaperone-mediated autophagy. [Abstract]2023 Jul:193:107161. PMID: 37163909 -
J Cardiothorac Surg
Interval training suppresses nod-like receptor protein 3 inflammasome activation to improve cardiac function in myocardial infarction rats by hindering the activation of the transforming growth factor-β1 pathway. [Abstract]2024 May 10;19(1):283. PMID: 38730417 -
Transplant Proc
2025 Aug 11:S0041-1345(25)00350-1. PMID: 40796392 -
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bioRxiv
Transgenic human dipeptidyl peptidase-4 Syrian hamsters support MERS coronavirus infection and contact transmission. [Abstract]2026 May 26:2026.05.26.725122. PMID: 42244650 -
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bioRxiv
2026 Mar 5:2026.03.04.708749. PMID: 41867811 -
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bioRxiv
Two axolotl-adapted cell-ablation platforms reveal macrophage-dependent processes essential for spinal-cord and skeletal regeneration. [Abstract]2026 Feb 12:2026.02.10.705144. PMID: 41727137 -
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bioRxiv
High-Throughput Screening on Primary Tumor-Associated Microglia and Macrophages Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Partners for Immunotherapy in Glioblastoma. [Abstract]2025 Mar 27:2025.03.24.645104. PMID: 40196519 -
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Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (333.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (333.33 mM)
* "≥" means soluble, but saturation unknown.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
View the Complete Stock Solution Preparation Table
Preparing Stock Solutions
View the Complete Stock Solution Preparation Table
Concentration
Solvent
Mass
1 mg
5 mg
10 mg
Concentration
Solvent
Mass
1 mM
3.3333 mL
16.6667 mL
33.3333 mL
5 mM
0.6667 mL
3.3333 mL
6.6667 mL
10 mM
0.3333 mL
1.6667 mL
3.3333 mL
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Calculadora de molaridad
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
=
×
×
Calculadora de dilución
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
Select Batch:
Pureza:
99.98%
Assay:
99.98%
ee.:
99.98%
-
Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[2]. Lee CC, et al. Structural basis of polyethylene glycol recognition by antibody. J Biomed Sci. 2020 Jan 7;27(1):12. [Content Brief]
[3]. Harris JM, et al. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2003 Mar;2(3):214-21. [Content Brief]
[4]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61. [Content Brief]
[5]. Ellen Weisberg, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20. [Content Brief]
View More
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.3333 mL | 16.6667 mL | 33.3333 mL | 83.3333 mL |
| 5 mM | 0.6667 mL | 3.3333 mL | 6.6667 mL | 16.6667 mL | |
| 10 mM | 0.3333 mL | 1.6667 mL | 3.3333 mL | 8.3333 mL | |
| 15 mM | 0.2222 mL | 1.1111 mL | 2.2222 mL | 5.5556 mL | |
| 20 mM | 0.1667 mL | 0.8333 mL | 1.6667 mL | 4.1667 mL | |
| 25 mM | 0.1333 mL | 0.6667 mL | 1.3333 mL | 3.3333 mL | |
| 30 mM | 0.1111 mL | 0.5556 mL | 1.1111 mL | 2.7778 mL | |
| 40 mM | 0.0833 mL | 0.4167 mL | 0.8333 mL | 2.0833 mL | |
| 50 mM | 0.0667 mL | 0.3333 mL | 0.6667 mL | 1.6667 mL | |
| 60 mM | 0.0556 mL | 0.2778 mL | 0.5556 mL | 1.3889 mL | |
| 80 mM | 0.0417 mL | 0.2083 mL | 0.4167 mL | 1.0417 mL | |
| 100 mM | 0.0333 mL | 0.1667 mL | 0.3333 mL | 0.8333 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PEG300 Related Classifications
HY-Y0873 Related Classifications
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