PF-9184
Based on 1 Customer Validation
PF-9184 is a potent and highly selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), with an IC50 of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro.
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- Pureza: 98.10%
- No. CAS: 1221971-47-6
- Fòrmula: C21H14Cl2N2O4S
- Peso molecular:461.32
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Almacenamiento:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
IC50: 16.5 nM (mPGES-1)[1]
PF-9184 (0.015-100 μM; 24 hours) inhibits IL-1β-stimulated prostaglandin E2 (PGE2) synthesis in rheumatoid arthritis (RASF) in synovial fibroblasts derived from patients and has no apparent cytotoxic effects up to 100 μM[1].
PF-9184 (0.015-100 μM) potently blocks mPGES-1 ability to synthesize PGE2 from PGH2, and with no apparent inhibitory effects on COX-2 and prostacyclin synthase in cells[1].
PF-9184 (0.015-100 μM) inhibits PGE2 weakly but has no effect on TXB2 synthesis except at 100 μM in human whole blood and modified blood assays[1].
PF-9184 is a poor inhibitor of recombinant rat mPGES-1 (IC50=1080±398 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1221971-47-6
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Appearance Solid
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Peso molecular 461.32
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Fòrmula C21H14Cl2N2O4S
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Color Off-white to light yellow
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SMILES
O=C(C1=C(O)C2=CC=CC=C2S(N1)(=O)=O)NC3=CC=C(C4=CC=C(Cl)C(Cl)=C4)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (216.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1677 mL | 10.8385 mL | 21.6769 mL | 54.1923 mL |
| 5 mM | 0.4335 mL | 2.1677 mL | 4.3354 mL | 10.8385 mL | |
| 10 mM | 0.2168 mL | 1.0838 mL | 2.1677 mL | 5.4192 mL | |
| 15 mM | 0.1445 mL | 0.7226 mL | 1.4451 mL | 3.6128 mL | |
| 20 mM | 0.1084 mL | 0.5419 mL | 1.0838 mL | 2.7096 mL | |
| 25 mM | 0.0867 mL | 0.4335 mL | 0.8671 mL | 2.1677 mL | |
| 30 mM | 0.0723 mL | 0.3613 mL | 0.7226 mL | 1.8064 mL | |
| 40 mM | 0.0542 mL | 0.2710 mL | 0.5419 mL | 1.3548 mL | |
| 50 mM | 0.0434 mL | 0.2168 mL | 0.4335 mL | 1.0838 mL | |
| 60 mM | 0.0361 mL | 0.1806 mL | 0.3613 mL | 0.9032 mL | |
| 80 mM | 0.0271 mL | 0.1355 mL | 0.2710 mL | 0.6774 mL | |
| 100 mM | 0.0217 mL | 0.1084 mL | 0.2168 mL | 0.5419 mL |
PF-9184 Related Classifications
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