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Referencia número: HY-133908

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PFI-3 Control

PFI-3 Control is an inactive analog of PFI-3 (HY-12409), serving as an inactive negative control. PFI-3 Control shows no detectable binding activity toward purified PB1 (5), SMARCA2A, SMARCA2B, and SMARCA4 family VIII bromodomain proteins.

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No. CAS: 1914047-60-1
Fòrmula: C₂₂H₂₃N₅O₃
Peso molecular:405.45

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

PFI-3 Control Chemical Structure

No. CAS: 1914047-60-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas SWI/SNF Complex :

In Vitro

PFI-3 Control (Compound 18) (100 nM-1 μM) fails to displace GFP-tagged PB1 from chromatin in SAHA (HY-10221)-treated U2OS cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1914047-60-1
Peso molecular 405.45
Fòrmula C₂₂H₂₃N₅O₃
SMILES

O=C(C1=CC=CC(OC)=C1O)/C=C/N2[C@@](C3)([H])CN(C4=NC=CC(NCC#C)=N4)[C@@]3([H])C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Gerstenberger BS, et al. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit. Journal of medicinal chemistry. 2016 May 26;59(10):4800-11. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PFI-3 Control

Ver todos los productos específicos de isoformas SWI/SNF Complex

Actividad biológica

Chemical Information

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PFI-3 Control Related Classifications

HY-133908 Related Classifications