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Referencia número: HY-170917

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PHD2-IN-4

PHD2-IN-4 (compound 1) is a PHD2 inhibitor. PHD2-IN-4 inhibits PHD2 with an IC₅₀ of 4 nM. PHD2-IN-4 is potential for chronic kidney disease research.

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No. CAS: 2924181-60-0
Fòrmula: C₂₁H₁₉N₅O₃
Peso molecular:389.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PHD2-IN-4 Chemical Structure

No. CAS: 2924181-60-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

PHD2-IN-4 (compound 1) is a PHD2 inhibitor. PHD2-IN-4 inhibits PHD2 with an IC₅₀ of 4 nM. PHD2-IN-4 is potential for chronic kidney disease research^[1].

IC₅₀ & Target^[1]

HIF-1α

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase :

Chemical Information

No. CAS 2924181-60-0
Peso molecular 389.41
Fòrmula C₂₁H₁₉N₅O₃
SMILES

O=C(C1=C(O)C2=C(C=N1)N=C(C=C2)N3CCOCC3)NCC4=CC=C(C#N)C=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 25;67(2):1393-1405. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PHD2-IN-4

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase

Actividad biológica

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Pureza y Documentación

Referencias

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PHD2-IN-4 Related Classifications

HY-170917 Related Classifications