Picoberin
Picoberin is a low picomolar inhibitor of Hedgehog-induced osteoblast differentiation. Picoberin is a potent aryl hydrocarbon receptor (AhR) agonist. Picoberin inhibits Wnt3A-induced osteoblast differentiation of C3H10T1/2 cells. Picoberin can upregulate genes encoding phase I and II metabolic enzymes.
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- No. CAS: 3034663-23-2
- Fòrmula: C17H13BrClNO
- Peso molecular:362.65
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C3H 10T1/2 | IC50 |
0.003 nM
Compound: 3l
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Inhibition of Hedgehog-signalling dependent purmorphamine induced osteoblast differentiation in mouse C3H 10T1/2 cells assessed as reduction in ALP expression incubated for 96 hrs by CDP-Star luminogenic substrate based assay
Inhibition of Hedgehog-signalling dependent purmorphamine induced osteoblast differentiation in mouse C3H 10T1/2 cells assessed as reduction in ALP expression incubated for 96 hrs by CDP-Star luminogenic substrate based assay
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[PMID: 36459434] |
Chemical Information
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No. CAS 3034663-23-2
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Peso molecular 362.65
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Fòrmula C17H13BrClNO
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SMILES
O=C1N2[C@@H](CC3=CC(Cl)=C(C=C31)Br)C4=C(CC2)C=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Picoberin Related Classifications
HY-148637 Related Classifications
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