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Referencia número: HY-189679

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PREP-IN-3

PREP-IN-3 is a mixed-type, selective prolyl endopeptidase (PREP) inhibitor. PREP-IN-3 can be used in research on neurological diseases.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1239312-95-8
Fòrmula: C₃₃H₄₄O₅
Peso molecular:520.70

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

PREP-IN-3 Chemical Structure

No. CAS: 1239312-95-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

PREP-IN-3 is a mixed-type, selective prolyl endopeptidase (PREP) inhibitor. PREP-IN-3 can be used in research on neurological diseases^[1].

In Vitro

PREP-IN-3 (Compound Ce-3) (5 min-2 h) inhibits PREP in mouse brain S9 fraction with an IC₅₀ of 3.89 µM and acts as a mixed-type inhibitor with a K_i of 4.17 µM^[1].
PREP-IN-3 selectively inhibits PREP over DPP4, DPP8, DPP9, and FAP, with IC₅₀ values >100 µM for all four off-target enzymes^[1].
PREP-IN-3 (up to 10 µM; 4 h) in HT22 and SH-SY5Y cells, after treatment at concentrations up to 10 µM for 4 h, cell viability was >90%^[1].
PREP-IN-3 (2-10 µM) inhibited endogenous PREP activity in HT22 and SH-SY5Y neuronal cells in a concentration-dependent manner, with relative fluorescence decreasing to 64.12% at 2 µM and to 28.13-32.56% at 10 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HT22 and SH-SY5Y cells
Concentration:

Up to 10 µM
Incubation Time:

4 h
Result:

Did not exhibit significant cytotoxicity (cell viability >90%) at concentrations up to 10 µM after 4 h.

Chemical Information

No. CAS 1239312-95-8
Peso molecular 520.70
Fòrmula C₃₃H₄₄O₅
SMILES

[H][C@@]12C[C@](C(O)=O)(CC[C@@]1(CC[C@@]3(C4=CC=C5C([C@@]4(CC[C@]32C)C)=CC(C(OC(CCC)=O)=C5C)=O)C)C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang TG, et al. Structure-based optimization, in vitro profiling, and ADMET prediction of Celastrol derivatives as potent prolyl endopeptidase inhibitors. Bioorganic chemistry. 2026 Aug 29;182:110457.

Calculators

Calculadora de molaridad

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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