Prometryn
Based on 1 publication(s) in Google Scholar
Prometryn is a triazine herbicide. Prometryn induces apoptosis and cell cycle arrest. Prometryn induces oxidative stress, DNA damage and autophagy-related gene expression, and non-specific immunity gene expression. Prometryn can be used for the research of herbicide, hepatopancreas injury, and intestinal stress and intestinal barrier dysfunction.
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- Pureza: 99.58%
- No. CAS: 7287-19-6
- Fòrmula: C10H19N5S
- Peso molecular:241.36
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Autophagy Compound Library
HY-L029
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Anti-Aging Compound Library
HY-L034
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Oxygen Sensing Compound Library
HY-L045
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Human Metabolite Library
HY-L123
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Pesticide Compound Library
HY-L183
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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Lactylation Compound Library
HY-L249
Publications Citing Use of MedChemExpress (MCE) Prometryn
More
Actividad biológica
Prometryn (25-200 μM; 24-48 h) decreases the viability of BEAS-2B cells in a time- and concentration-dependent manner[1].
Prometryn (25-200 μM; 24-48 h) induces S phase cell cycle arrest in BEAS-2B cells at concentrations of 100 and 200 μM after 48 h of exposure, accompanied by reduced cyclin A and CDK2 expression and increased p53 expression[1].
Prometryn (25-200 μM; 48 h) induces apoptosis in BEAS-2B cells in a concentration-dependent manner at 100 and 200 μM after 48 h of exposure, mediated by altered expression of Bcl2, Bax, Caspase 9, Caspase 3, and PARP[1].
Prometryn (25-200 μM; 48 h) induces dose-dependent intracellular ROS generation in BEAS-2B cells, with significant increases detected at 200 μM after 48 h of exposure[1].
Prometryn (25-200 μM; 48 h) induces dose-dependent DNA damage in BEAS-2B cells[1].
Prometryn (5-20 mg/L; 96 hours) induces dose-dependent developmental toxicity in Danio rerio embryos over 96 hours, causing morphological defects, organogenesis failure, oxidative stress, apoptosis, and mitochondrial dysfunction, with an LC50 value of 23.14 mg/L[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human bronchial epithelial BEAS-2B cells
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Concentration:25 μM; 50 μM; 100 μM; 200 μM
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Incubation Time:24 h; 48 h
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Result:Decreased BEAS-2B cell viability significantly at 100-200 μM after 48 h incubation (P < 0.01).
Showed no significant viability reduction after 24 h of treatment at any tested concentration.
Induced morphological changes including reduced cell volume, rounded cell shape, loss of intercellular connections, floating cells, and cell debris in cells treated with 50-200 μM for 48 h.
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Cell Line:human bronchial epithelial BEAS-2B cells
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Concentration:25 μM; 50 μM; 100 μM; 200 μM
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Incubation Time:24 h; 48 h
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Result:Decreased the proportion of BEAS-2B cells in the G1 phase and increased the proportion in the S phase at 100 and 200 μM after 48 h incubation (P < 0.05), indicating S phase cell cycle arrest.
Reduced cyclin A and CDK2 protein expression in a dose-dependent manner via western blotting.
Increased p53 protein expression in a dose-dependent manner via western blotting.
Showed no cell cycle effects after 24 h of treatment at any concentration.
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Cell Line:human bronchial epithelial BEAS-2B cells
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Concentration:25 μM; 50 μM; 100 μM; 200 μM
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Incubation Time:48 h
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Result:Induced apoptosis in BEAS-2B cells at 100 μM with an apoptotic rate of ~6.5% (P < 0.01).
Induced apoptosis in BEAS-2B cells at 200 μM with an apoptotic rate of ~9% (P < 0.001).
Reduced anti-apoptotic Bcl2 protein expression in a dose-dependent manner via western blotting.
Increased pro-apoptotic Bax protein expression in a dose-dependent manner via western blotting.
Reduced expression of full-length Caspase 9, Caspase 3, and PARP via western blotting.
Increased expression of cleaved, active forms of Caspase 9, Caspase 3, and PARP via western blotting.
Chemical Information
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No. CAS 7287-19-6
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Appearance Solid
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Peso molecular 241.36
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Fòrmula C10H19N5S
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Color White to off-white
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SMILES
CSC1=NC(NC(C)C)=NC(NC(C)C)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 100 mg/mL (414.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Liu Q, et al. Prometryn induces apoptotic cell death through cell cycle arrest and oxidative DNA damage. Toxicol Res (Camb). 2019;8(6):833-841. Published 2019 Jul 26. [Content Brief]
[2]. Huang P, et al. Effects of prometryn on oxidative stress, immune response and apoptosis in the hepatopancreas of Eriocheir sinensis (Crustacea: Decapoda). Ecotoxicol Environ Saf. Published online June 23, 2023. [Content Brief]
[3]. Huang P, et al. Prometryn exposure disrupts the intestinal health of Eriocheir sinensis: Physiological responses and underlying mechanism. Comp Biochem Physiol C Toxicol Pharmacol. 2024;277:109820. [Content Brief]
[4]. Min N, et al. Developmental toxicity of prometryn induces mitochondrial dysfunction, oxidative stress, and failure of organogenesis in zebrafish (Danio rerio). J Hazard Mater. 2023;443(Pt A):130202. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1432 mL | 20.7159 mL | 41.4319 mL | 103.5797 mL |
| 5 mM | 0.8286 mL | 4.1432 mL | 8.2864 mL | 20.7159 mL | |
| 10 mM | 0.4143 mL | 2.0716 mL | 4.1432 mL | 10.3580 mL | |
| 15 mM | 0.2762 mL | 1.3811 mL | 2.7621 mL | 6.9053 mL | |
| 20 mM | 0.2072 mL | 1.0358 mL | 2.0716 mL | 5.1790 mL | |
| 25 mM | 0.1657 mL | 0.8286 mL | 1.6573 mL | 4.1432 mL | |
| 30 mM | 0.1381 mL | 0.6905 mL | 1.3811 mL | 3.4527 mL | |
| 40 mM | 0.1036 mL | 0.5179 mL | 1.0358 mL | 2.5895 mL | |
| 50 mM | 0.0829 mL | 0.4143 mL | 0.8286 mL | 2.0716 mL | |
| 60 mM | 0.0691 mL | 0.3453 mL | 0.6905 mL | 1.7263 mL | |
| 80 mM | 0.0518 mL | 0.2589 mL | 0.5179 mL | 1.2947 mL | |
| 100 mM | 0.0414 mL | 0.2072 mL | 0.4143 mL | 1.0358 mL |
Prometryn Related Classifications
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