PU3
PU3 is an Hsp90 inhibitor that competes with geldanamycin (GM) and others for the conserved ATP/ADP pocket of Hsp90. PU3 also induces degradation of proteins such as Her2 and inhibits breast cancer cell growth by causing retinoblastoma protein hypophosphorylation, G1 arrest, and cell differentiation. PU3 has the potential to be a cancer inhibitor..
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- No. CAS: 352519-21-2
- Fòrmula: C19H25N5O3
- Peso molecular:371.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Hsp90[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
1 μM
Compound: 19, PU3
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Inhibition of Hsp90 in human MCF7 cells assessed as Her2 degradation
Inhibition of Hsp90 in human MCF7 cells assessed as Her2 degradation
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[PMID: 19017562] |
| NCI-H1975 | GI50 |
50 μM
Compound: 3, PU3
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Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 to 3 days by MTS assay
Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 to 3 days by MTS assay
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[PMID: 24345447] |
Chemical Information
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No. CAS 352519-21-2
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Peso molecular 371.43
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Fòrmula C19H25N5O3
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SMILES
NC1=C2N=C(N(C2=NC=N1)CCCC)CC3=CC(OC)=C(C(OC)=C3)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PU3 Related Classifications
HY-121881 Related Classifications
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