PV1162
PV1162 is a selective Chk2 inhibitor with an IC50 of 0.29 nM. PV1162 inhibits ATP binding to Chk2 by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to Chk2 and located behind the ATP-binding site (adenine-binding region), thereby inhibiting the phosphorylation activity of Chk2. PV1162 holds potential application value in the field of cancer therapy.
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- No. CAS: 1093793-11-3
- Fòrmula: C21H24N6O2
- Peso molecular:392.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Chk1 59000 nM (IC50) |
Chk2 0.29 nM (IC50) |
Chemical Information
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No. CAS 1093793-11-3
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Peso molecular 392.45
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Fòrmula C21H24N6O2
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SMILES
O=C(C(N1)=CC2=C1C=CC(OC)=C2)NC3=CC=C(/C(CCC)=N/NC(N)=N)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PV1162 Related Classifications
HY-164523 Related Classifications
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