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Referencia número: HY-143659

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QW30

QW30 (Compound 19) shows potent antitumor activity with an IC₅₀ value of 0.33 μM.

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No. CAS: 1714112-25-0
Fòrmula: C₂₇H₃₆N₂O₃
Peso molecular:436.59

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

QW30 Chemical Structure

No. CAS: 1714112-25-0

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Actividad biológica

Descripciòn

QW30 (Compound 19) shows potent antitumor activity with an IC₅₀ value of 0.33 μM.

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	0.28 μM Compound: 19; QW30	Antiproliferative activity against human DU145 cells after 96 hrs by SRB assay Antiproliferative activity against human DU145 cells after 96 hrs by SRB assay	[PMID: 27187855]
HCT-116	IC₅₀	0.57 μM Compound: 19; QW30	Antiproliferative activity against human HCT116 cells after 96 hrs by SRB assay Antiproliferative activity against human HCT116 cells after 96 hrs by SRB assay	[PMID: 27187855]
HL-60	IC₅₀	0.04 μM Compound: 19; QW30	Antiproliferative activity against human HL60 cells after 96 hrs by SRB assay Antiproliferative activity against human HL60 cells after 96 hrs by SRB assay	[PMID: 27187855]
HT-29	IC₅₀	0.59 μM Compound: 19; QW30	Antiproliferative activity against human HT-29 cells after 96 hrs by SRB assay Antiproliferative activity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 27187855]
MCF7	IC₅₀	0.28 μM Compound: 19; QW30	Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 27187855]
MDA-MB-231	IC₅₀	0.32 μM Compound: 19; QW30	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by SRB assay	[PMID: 27187855]
PC-3	IC₅₀	0.54 μM Compound: 19; QW30	Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay	[PMID: 27187855]
T47D	EC₅₀	2.56 nM Compound: 19; QW30	Inhibition of colony formation in human T47D cells after 7 days by crystal violet staining based assay Inhibition of colony formation in human T47D cells after 7 days by crystal violet staining based assay	[PMID: 27187855]
T47D	EC₅₀	6.42 μM Compound: 19; QW30	Antimigratory activity in human T47D cells assessed as inhibition of cell migration after 12 hrs by crystal violet staining based transwell migration assay Antimigratory activity in human T47D cells assessed as inhibition of cell migration after 12 hrs by crystal violet staining based transwell migration assay	[PMID: 27187855]
T47D	IC₅₀	0.01 μM Compound: 19; QW30	Antiproliferative activity against human T47D cells after 96 hrs by SRB assay Antiproliferative activity against human T47D cells after 96 hrs by SRB assay	[PMID: 27187855]

Chemical Information

No. CAS 1714112-25-0
Peso molecular 436.59
Fòrmula C₂₇H₃₆N₂O₃
SMILES

CC1(C)[C@@H](O)CC[C@]2(C)C3=C(C=C(C(NC4=CC=C(N(C)C)C=C4)=O)C(OC)=C3)CC[C@@]12[H]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.