Rubropunctatin
Based on 1 publication(s) in Google Scholar
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.
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- Pureza: 98.0%
- No. CAS: 514-67-0
- Fòrmula: C21H22O5
- Peso molecular:354.40
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Rubropunctatin
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
28.2 μM
Compound: 9
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Antiproliferative activity against human A431 cells after 72 hrs
Antiproliferative activity against human A431 cells after 72 hrs
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[PMID: 20655237] |
| IGROV-1 | IC50 |
28.2 μM
Compound: 9
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Antiproliferative activity against human IGROV1 cells after 72 hrs
Antiproliferative activity against human IGROV1 cells after 72 hrs
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[PMID: 20655237] |
| NCI-H460 | IC50 |
>50 μM
Compound: 9
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Antiproliferative activity against human NCI-H460 cells after 72 hrs
Antiproliferative activity against human NCI-H460 cells after 72 hrs
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[PMID: 20655237] |
Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1[1].
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells[1].
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BGC-823 and GES-1cells
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Concentration:1.5, 3, 6, 12, 15, 18, 30 μM
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Incubation Time:24 hours
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Result:Decreased the viability of BGC-823 cells with an IC50 of 12.57 μM for 24 h.
Did not show obvious cytotoxic effects on the normal cells.
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Cell Line:BGC-823 cells
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Concentration:0, 5, 10, 30 μM
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Incubation Time:0, 6, 12, 24 hours
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Result:Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.
Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID50 of 0.11 mg/ear[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male nude mice (5 weeks) are inoculated with BGC-823 cells[1]
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Dosage:8, 32 mg/kg
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Administration:I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
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Result:Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).
Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).
No significant difference was observed on the body weight.
Chemical Information
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No. CAS 514-67-0
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Appearance Solid
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Peso molecular 354.40
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Fòrmula C21H22O5
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Color Yellow to orange
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SMILES
O=C(O1)C(C(CCCCC)=O)=C2[C@]1(C)C(C3=COC(/C=C/C)=CC3=C2)=O
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Structure Classification
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Initial Source
Monascus purpureus
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Spectrochim Acta A Mol Biomol Spectrosc
Active pharmaceutical ingredient-correlated wavelength selection of UV-vis spectroscopy for the rapid quality assessment of red yeast Rice. [Abstract]2026 Jul 5:355:127669. PMID: 41785610
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zheng Y, et, al. Anti-cancer effect of rubropunctatin against human gastric carcinoma cells BGC-823. Appl Microbiol Biotechnol. 2010 Nov;88(5):1169-77. [Content Brief]
[2]. Dhale MA, et, al. Protective and antioxidative effect of rubropunctatin against oxidative protein damage induced by metal catalyzed reaction. Int J Biol Macromol. 2018 Sep;116:409-416. [Content Brief]
[3]. Akihisa T, et, al. Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects. J Agric Food Chem. 2005 Feb 9;53(3):562-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rubropunctatin Related Classifications
HY-N7766 Related Classifications
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