S-309309
Based on 1 Customer Validation
S-309309 is an orally active and selective MGAT2 inhibitor. S-309309 can be used in metabolism-related research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.55%
- No. CAS: 2267352-04-3
- Fòrmula: C23H21F2N5O5S
- Peso molecular:517.51
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Metabolism/Protease Compound Library
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Clinical Compound Library
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Drug Repurposing Compound Library
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Orally Active Compound Library
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Anti-Obesity Compound Library
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Lipid Metabolism Compound Library
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Metabolic Enzyme Compound Library
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Drug Repurposing Compound Library Plus
HY-L035P
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Clinical Compound Library Plus
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Actividad biológica
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MGAT2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:High fat diet (HFD)-induced obesity (DIO) mice[1]
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Dosage:3 mg/kg
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Administration:p.o., b.i.d., 6-13 weeks
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Result:Decreased in insulin resistance index, hepatic triglycerides content, plasma alanine aminotransferase and aspartate aminotransferase level, and gene expression related to fibrosis.
Enhanced energy expenditure and upregulation of intestinal gene expression related to long-chain fatty acid beta oxidation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2267352-04-3
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Appearance Solid
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Peso molecular 517.51
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Fòrmula C23H21F2N5O5S
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Color White to off-white
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SMILES
FC1=CC(F)=CC2=C1[C@]3(NC(C4=C(NC(CS(C)(=O)=O)=O)N(C5=CC=C(C)C=N5)N=C4C3)=O)CCO2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 100 mg/mL (193.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9323 mL | 9.6616 mL | 19.3233 mL | 48.3082 mL |
| 5 mM | 0.3865 mL | 1.9323 mL | 3.8647 mL | 9.6616 mL | |
| 10 mM | 0.1932 mL | 0.9662 mL | 1.9323 mL | 4.8308 mL | |
| 15 mM | 0.1288 mL | 0.6441 mL | 1.2882 mL | 3.2205 mL | |
| 20 mM | 0.0966 mL | 0.4831 mL | 0.9662 mL | 2.4154 mL | |
| 25 mM | 0.0773 mL | 0.3865 mL | 0.7729 mL | 1.9323 mL | |
| 30 mM | 0.0644 mL | 0.3221 mL | 0.6441 mL | 1.6103 mL | |
| 40 mM | 0.0483 mL | 0.2415 mL | 0.4831 mL | 1.2077 mL | |
| 50 mM | 0.0386 mL | 0.1932 mL | 0.3865 mL | 0.9662 mL | |
| 60 mM | 0.0322 mL | 0.1610 mL | 0.3221 mL | 0.8051 mL | |
| 80 mM | 0.0242 mL | 0.1208 mL | 0.2415 mL | 0.6039 mL | |
| 100 mM | 0.0193 mL | 0.0966 mL | 0.1932 mL | 0.4831 mL |
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