SANT 2
Based on 1 Customer Validation
SANT 2 is a potent Hh-signaling pathway antagonist. SANT 2 interferes with the expression of Gli1. SANT 2 causes developmental delay in medaka embryos. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.41%
- No. CAS: 329196-48-7
- Fòrmula: C26H26ClN3O4
- Peso molecular:479.96
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C3H 10T1/2 | IC50 |
30 nM
Compound: 51, SANT-2
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Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay
Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay
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[PMID: 19309080] |
| Shh Light II | IC50 |
97.9 nM
Compound: 6, SANT-2
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Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG
Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG
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[PMID: 19541490] |
SANT-2 (48 h) interferes with the expression of the Hh target gene Gli1 in Shh-Light II cells (IC50 of 97.9 nM)[1].
SANT 2 (0.01-100 μM; from 4-5 h post-fertilization until 5 days post-fertilization) does not induce the cyclopia phenotype in medaka embryos, but causes developmental delays at concentrations close to lethality[1].
SANT 2 (5 h for radioligand binding assay, 40-48 h for β-lactamase reporter gene assay) shows allosteric inhibition of [3H]SAG-1.3 binding to Smo receptors in radioligand binding assays and fully inhibits SAG-1.5-induced Hh pathway activation in a β-lactamase reporter gene assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 329196-48-7
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Appearance Solid
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Peso molecular 479.96
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Fòrmula C26H26ClN3O4
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Color White to off-white
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SMILES
ClC1=CC=C(NC(C2=CC(OCC)=C(OCC)C(OCC)=C2)=O)C=C1C3=NC4=CC=CC=C4N3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 250 mg/mL (520.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17(14):4943-54. [Content Brief]
[2]. Rominger CM, et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther. 2009 Jun;329(3):995-1005. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0835 mL | 10.4175 mL | 20.8351 mL | 52.0877 mL |
| 5 mM | 0.4167 mL | 2.0835 mL | 4.1670 mL | 10.4175 mL | |
| 10 mM | 0.2084 mL | 1.0418 mL | 2.0835 mL | 5.2088 mL | |
| 15 mM | 0.1389 mL | 0.6945 mL | 1.3890 mL | 3.4725 mL | |
| 20 mM | 0.1042 mL | 0.5209 mL | 1.0418 mL | 2.6044 mL | |
| 25 mM | 0.0833 mL | 0.4167 mL | 0.8334 mL | 2.0835 mL | |
| 30 mM | 0.0695 mL | 0.3473 mL | 0.6945 mL | 1.7363 mL | |
| 40 mM | 0.0521 mL | 0.2604 mL | 0.5209 mL | 1.3022 mL | |
| 50 mM | 0.0417 mL | 0.2084 mL | 0.4167 mL | 1.0418 mL | |
| 60 mM | 0.0347 mL | 0.1736 mL | 0.3473 mL | 0.8681 mL | |
| 80 mM | 0.0260 mL | 0.1302 mL | 0.2604 mL | 0.6511 mL | |
| 100 mM | 0.0208 mL | 0.1042 mL | 0.2084 mL | 0.5209 mL |
SANT 2 Related Classifications
HY-107408 Related Classifications
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