SCH 221510
Based on 1 Customer Validation
SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.06%
- No. CAS: 322473-89-2
- Fòrmula: C28H31NO
- Peso molecular:397.55
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-107722R
SCH 221510 (Standard)Reference Standard -
HY-P0183
NociceptinNociceptin Receptor Ligand -
HY-107721
(±)-J-113397ORL1 Receptor Antagonist -
HY-14157
ADL-5747DOR Agonist -
HY-P1302
Orphanin FQ(1-11)NOP/OP4 Receptor Agonist -
HY-P1319
Nociceptin(1-7)NOP Receptor Agonist -
HY-13222A
BAN ORL 24 free baseNOP Receptor Antagonist -
![[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2](https://file.medchemexpress.com/product_pic/hy-p0192.gif)
HY-P0192
[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2ORL1 Agonist -
HY-11052A
Trap-101 hydrochlorideNOP receptor Antagonist -
HY-18617
rel-SB-612111 hydrochlorideORL-1 Inhibitor -
HY-P0193
Nocistatin (Bovine)Nociceptin Precursor
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Actividad biológica
Descripciòn
IC50 & Target
EC50: 12 nM (NOP)[1]
Chemical Information
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No. CAS 322473-89-2
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Appearance Solid
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Peso molecular 397.55
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Fòrmula C28H31NO
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Color White to off-white
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SMILES
O[C@](C[C@H]1CC2)(C3=CC=CC=C3)C[C@H]2N1C(C4=C(C=CC=C4)C)C5=C(C=CC=C5)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (125.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5154 mL | 12.5770 mL | 25.1541 mL | 62.8852 mL |
| 5 mM | 0.5031 mL | 2.5154 mL | 5.0308 mL | 12.5770 mL | |
| 10 mM | 0.2515 mL | 1.2577 mL | 2.5154 mL | 6.2885 mL | |
| 15 mM | 0.1677 mL | 0.8385 mL | 1.6769 mL | 4.1923 mL | |
| 20 mM | 0.1258 mL | 0.6289 mL | 1.2577 mL | 3.1443 mL | |
| 25 mM | 0.1006 mL | 0.5031 mL | 1.0062 mL | 2.5154 mL | |
| 30 mM | 0.0838 mL | 0.4192 mL | 0.8385 mL | 2.0962 mL | |
| 40 mM | 0.0629 mL | 0.3144 mL | 0.6289 mL | 1.5721 mL | |
| 50 mM | 0.0503 mL | 0.2515 mL | 0.5031 mL | 1.2577 mL | |
| 60 mM | 0.0419 mL | 0.2096 mL | 0.4192 mL | 1.0481 mL | |
| 80 mM | 0.0314 mL | 0.1572 mL | 0.3144 mL | 0.7861 mL | |
| 100 mM | 0.0252 mL | 0.1258 mL | 0.2515 mL | 0.6289 mL |
SCH 221510 Related Classifications
HY-107722 Related Classifications
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