Semax
Based on 1 publication(s) in Google Scholar
Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia.
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- Pureza: 99.56%
- No. CAS: 80714-61-0
- Fòrmula: C37H51N9O10S
- Peso molecular:813.92
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Semax
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Actividad biológica
Semax (25-100 μM, 48 h) can reduce the levels of Aβ oligomers[1].
Semax (100 nM) can increase the survival rate of cholinergic neurons in the basal forebrain and stimulate the activity of choline acetyltransferase in cultured basal forebrain tissue ex vivo[2].
Semax (10 μM, 0-4 h) can increase the levels of BDNF and NGF in glial cells derived from the basal forebrain of newborn rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Glial cells derived from the basal forebrain of newborn rats
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Concentration:10 μM
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Incubation Time:0, 0.5, 1, 2, 3, 4, 8, 16 and 24 h
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Result:Increased the mRNA levels of the BDNF and NGF.
Semax (0.15 mg/kg; intraperitoneal injection; single dose) can increase the concentration of 5-HIAA in the hypothalamus and striatum of mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ischemia (pMCAO) rats[4]
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Dosage:100 μg/kg
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Administration:Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO).
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Result:Affected the expression of genes related to the immune system. At 3 hours after pMCAO, it influenced the expression of genes regulating the activity of immune cells such as macrophages, neutrophils, and lymphocytes. At 24 hours after pMCAO, the effect on the immune response was significantly increased, with over 50% of the genes with altered expression involved in the immune response.
Affected the expression of genes related to the vascular system. At 3 hours after pMCAO, it influenced genes involved in vasculogenesis, hematopoiesis, and endothelial cell migration. At 24 hours after pMCAO, it affected the development of endothelial tissue, the migration of smooth muscle cells, and the activation of blood cells.
Chemical Information
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No. CAS 80714-61-0
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Appearance Solid
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Peso molecular 813.92
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Fòrmula C37H51N9O10S
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Color White to off-white
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Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
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Sequence Shortening
MEHFPGP
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 100 mg/mL (122.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (122.86 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Sciacca MFM, et al. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13(4):486-496. [Content Brief]
[2]. Grivennikov IA, et al. Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons. Restor Neurol Neurosci. 2008;26(1):35-43. [Content Brief]
[3]. Shadrina MI, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308(2):115-8. [Content Brief]
[4]. Medvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. [Content Brief]
[5]. Eremin KO, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30(12):1493-500. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.2286 mL | 6.1431 mL | 12.2862 mL | 30.7156 mL |
| 5 mM | 0.2457 mL | 1.2286 mL | 2.4572 mL | 6.1431 mL | |
| 10 mM | 0.1229 mL | 0.6143 mL | 1.2286 mL | 3.0716 mL | |
| 15 mM | 0.0819 mL | 0.4095 mL | 0.8191 mL | 2.0477 mL | |
| 20 mM | 0.0614 mL | 0.3072 mL | 0.6143 mL | 1.5358 mL | |
| 25 mM | 0.0491 mL | 0.2457 mL | 0.4914 mL | 1.2286 mL | |
| 30 mM | 0.0410 mL | 0.2048 mL | 0.4095 mL | 1.0239 mL | |
| 40 mM | 0.0307 mL | 0.1536 mL | 0.3072 mL | 0.7679 mL | |
| 50 mM | 0.0246 mL | 0.1229 mL | 0.2457 mL | 0.6143 mL | |
| 60 mM | 0.0205 mL | 0.1024 mL | 0.2048 mL | 0.5119 mL | |
| 80 mM | 0.0154 mL | 0.0768 mL | 0.1536 mL | 0.3839 mL | |
| 100 mM | 0.0123 mL | 0.0614 mL | 0.1229 mL | 0.3072 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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