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Referencia número: HY-N19943

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Siegeside B

Siegeside B is a diterpenoid glycoside found in the dried aerial parts of Siegesbeckia pubescens. Siegeside B inhibits epidermal growth factor-induced migration and invasion of breast cancer cells. Siegeside B can be used for the research of breast cancer.

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No. CAS: 2095244-07-6
Fòrmula: C₂₆H₄₄O₈
Peso molecular:484.62

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Siegeside B Chemical Structure

No. CAS: 2095244-07-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	0.27 μM Compound: 2	Inhibition of EGF-induced invasion of human MDA-MB-231 cells by MTT assay Inhibition of EGF-induced invasion of human MDA-MB-231 cells by MTT assay	[PMID: 28302401]
RAW264.7	IC₅₀	100 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS challenge measured after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS challenge measured after 24 hrs by Griess assay	[PMID: 28302401]

In Vitro

Siegeside B potently inhibits EGF-induced invasion of MB-MDA-231 breast cancer cells with an IC₅₀ of 0.27 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

No. CAS 2095244-07-6
Peso molecular 484.62
Fòrmula C₂₆H₄₄O₈
SMILES

C[C@]12[C@@]3([H])C(CC[C@]1([H])C(C)([C@@H](CC2)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)C)=C[C@](C)(CC3)[C@H](O)CO
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang J, et al. Isolation and characterization of diterpene glycosides from Siegesbeckia pubescens. Bioorg Med Chem Lett. 2017;27(8):1815-1819. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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