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Referencia número: HY-187472

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SMA-245

SMA-245 is an inhibitor of Filovirus glycoproteins, acting on Ebola virus (EBOV) and Marburg virus (MARV). SMA-245 blocks the endosomal membrane fusion step of filoviruses by binding to the EBOV GP1/GP2 fusion loop. SMA-245 inhibits MARV viral entry. SMA-245 can be used in research related to filovirus infections.

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Fòrmula: C₂₉H₃₂N₂O₂
Peso molecular:440.58

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMA-245 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

EBOV

MARV

Ver todos los productos específicos de isoformas Filovirus :

Ver todos los productos específicos de isoformas Cytochrome P450 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	6.8 μM	Cytotoxicity against human A549 lung epithelial cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation. Cytotoxicity against human A549 lung epithelial cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation.	42475249
HeLa	CC₅₀	4.6 μM	Cytotoxicity against human HeLa cervical cancer cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation. Cytotoxicity against human HeLa cervical cancer cells measured via CellTiter-Glo Luminescent Cell Viability Assay after 48 h incubation.	42475249

In Vitro

SMA-245 (compound 41) (48 h) potently inhibits pEBOV entry in A549 cells with an EC₅₀ of 0.040 μM, also inhibits pMARV, pSUDV, and pTAFV entry, shows no activity against pBDBV, and has low activity against non-filovirus pseudoviruses^[1].
SMA-245 (40 h infection incubation; 48 h cytotoxicity incubation) potently inhibits infectious EBOV replication in HeLa cells with an EC₅₀ of 0.04 μM and infectious MARV replication with an EC₅₀ of 0.38 μM, with selectivity indices of 120 and 12, respectively^[1].
SMA-245 moderately inhibits hERG potassium channels with an IC₅₀ of 2.93 μM, representing a potential cardiac safety concern^[1].
SMA-245 has excellent plasma stability in human and mouse, high stability in human liver microsomes, moderate stability in mouse liver microsomes, and low to moderate inhibition of major CYP450 isoforms at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_last	AUC_0-∞	T_1/2	MRT_0-∞	C₀	CL	V_ss	T_max	C_max	C_min	Bioavailability
Mice^[1]	5 mg/kg	i.v.	2416 ng·h/mL	2585 ng·h/mL	6.8 h	7.1 h	1224 ng/mL	32 mL/min/kg	14 L/kg	/	/	/	/
Mice^[1]	50 mg/kg	p.o.	1637 ng·h/mL	1672 ng·h/mL	4.1 h	5.8 h	/	/	/	4.0 h	210 ng/mL	5.8 ng/mL	6.47 %

In Vivo

SMA-245 (compound 41) (5-50 mg/kg; i.v., p.o.; single bolus) exhibits favorable in vivo pharmacokinetic properties following i.v. administration in male BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 440.58
Fòrmula C₂₉H₃₂N₂O₂
SMILES

COC1=CC2=C(C(C(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)NC(C5CCNCC5)=O)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Aboukhatwa SM, et al. Configurationally Locked Ridaifen-B Analogs as Potent Ebola Virus Entry Inhibitors. Journal of medicinal chemistry. 2026 Jul 20.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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SMA-245

Ver todos los productos específicos de isoformas Filovirus

Ver todos los productos específicos de isoformas Cytochrome P450