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Referencia número: HY-P11863

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SMIC-1014

SMIC-1014 is a cellular mesenchymal-epithelial transition factor (c-Met) ligand. SMIC-1014 binds to the c-Met ectodomain without activating c-Met phosphorylation or inducing receptor internalization. SMIC-1014, when radiolabeled as [⁶⁸Ga]Ga-SMIC-1014, acts as a positron emission tomography (PET) probe with defined pharmacokinetics, achieves specific tumor uptake in xenografts, and functions as a c-Met-targeted diagnostic probe. SMIC-1014 can be used for the research of colon cancer, hepatocellular carcinoma, prostate cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₅₂H₈₀N₁₆O₁₆
Peso molecular:1185.29

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

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SMIC-1014 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Bioz

Actividad biológica

Descripciòn

SMIC-1014 is a cellular mesenchymal-epithelial transition factor (c-Met) ligand. ^[1] SMIC-1014 binds to the c-Met ectodomain without activating c-Met phosphorylation or inducing receptor internalization. ^[1] SMIC-1014, when radiolabeled as [⁶⁸Ga]Ga-SMIC-1014, acts as a positron emission tomography (PET) probe with defined pharmacokinetics, achieves specific tumor uptake in xenografts, and functions as a c-Met-targeted diagnostic probe. ^[2] SMIC-1014 can be used for the research of colon cancer, hepatocellular carcinoma, prostate cancer^[1].

In Vitro

SMIC-1014 (10^-3 to 10^-10 M; 60 min) competes with [⁶⁸Ga]Ga-SMIC-1014 for binding to c-Met on HCT-116 cells, with an IC₅₀ of 116.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 1185.29
Fòrmula C₅₂H₈₀N₁₆O₁₆
Sequence

{βAla}-d{Arg-Leu-Asp}-Gly-d{Pro-Glu}-Gly-d{Pro-Phe-Gln}-NH2
Sequence Shortening

{βAla}-d{RLD}-G-d{PE}-G-d{PFQ}-NH2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Luo R, et al.. Harnessing Insights of Hepatocyte Growth Factor Kringle 3 Domain to Develop c-Met Targeted Positron Emission Tomography Probe. Journal of medicinal chemistry. 2026 Jan 08;69(1):488-500. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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