country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-120313

Copy Link Print Information

SN23862

SN23862 is a cancer prodrug with anti-cancer activity, and an analogue of CB-1954 (HY-13543). SN23862 can be used for cancer research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 142439-61-0
Fòrmula: C₁₁H₁₂Cl₂N₄O₅
Peso molecular:351.14

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SN23862 Chemical Structure

No. CAS: 142439-61-0

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

SN23862 is a cancer prodrug with anti-cancer activity, and an analogue of CB-1954 (HY-13543). SN23862 can be used for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-AA8	IC₅₀	470 μM Compound: 20	Growth inhibition of aerobic chinese hamster ovary fibroblast AA8 cell line using an exposure time of 18 hours Growth inhibition of aerobic chinese hamster ovary fibroblast AA8 cell line using an exposure time of 18 hours	[PMID: 1507207]
CHO-AA8	IC₅₀	1600 μM Compound: 1	Cytotoxicity in a growth inhibition assay against aerobic cultures of AA8 cells was determined Cytotoxicity in a growth inhibition assay against aerobic cultures of AA8 cells was determined	[PMID: 7707325]
CHO-AA8	IC₅₀	470 μM Compound: 6	Aerobic cytotoxicity was assessed in a growth inhibition assay using log phase cultures of the chinese hamster ovary fibroblast line AA8 Aerobic cytotoxicity was assessed in a growth inhibition assay using log phase cultures of the chinese hamster ovary fibroblast line AA8	[PMID: 8035424]
CHO-AA8	IC₅₀	1600 μM Compound: 2a	Compound was tested for aerobic growth inhibition against AA8 cells after 4 hr of exposure Compound was tested for aerobic growth inhibition against AA8 cells after 4 hr of exposure	[PMID: 8691449]
CHO-AA8	IC₅₀	470 μM Compound: 2a	Inhibition of growth under aerobic conditions in AA8 cells Inhibition of growth under aerobic conditions in AA8 cells	[PMID: 8691449]
CHO-AA8	IC₅₀	1450 μM Compound: 1	Aerobic cytotoxic activity was evaluated by the growth inhibition of AA8 (chinese hamster) aerobic cells Aerobic cytotoxic activity was evaluated by the growth inhibition of AA8 (chinese hamster) aerobic cells	[PMID: 9873426]
EMT6	IC₅₀	1.85 μM Compound: 4	Antiproliferative activity against mouse EMT6 NTRpuro cells after 18 hrs Antiproliferative activity against mouse EMT6 NTRpuro cells after 18 hrs	[PMID: 17326614]
EMT6	IC₅₀	442 μM Compound: 4	Antiproliferative activity against mouse wild type EMT6 NTR-ve cells after 18 hrs Antiproliferative activity against mouse wild type EMT6 NTR-ve cells after 18 hrs	[PMID: 17326614]
SK-OV-3	IC₅₀	>1000 μM Compound: 1	Aerobic cytotoxic activity was evaluated by the growth inhibition of SKOV (human ovarian cancer line) aerobic cells Aerobic cytotoxic activity was evaluated by the growth inhibition of SKOV (human ovarian cancer line) aerobic cells	[PMID: 9873426]
T78-1	IC₅₀	895 μM Compound: 4	Cytotoxicity in T78-1 (NR-negative) cell lines Cytotoxicity in T78-1 (NR-negative) cell lines	[PMID: 9111301]
UV4	IC₅₀	108 μM Compound: 20	Growth inhibition of aerobic chinese hamster ovary fibroblast UV4 cells using an exposure time of 18 hours Growth inhibition of aerobic chinese hamster ovary fibroblast UV4 cells using an exposure time of 18 hours	[PMID: 1507207]
UV4	IC₅₀	960 μM Compound: 1	Cytotoxicity in a growth inhibition assay against aerobic cultures of UV4 cells was determined Cytotoxicity in a growth inhibition assay against aerobic cultures of UV4 cells was determined	[PMID: 7707325]
UV4	IC₅₀	870 μM Compound: 1	Aerobic cytotoxic activity was evaluated by the growth inhibition of UV4 aerobic cells Aerobic cytotoxic activity was evaluated by the growth inhibition of UV4 aerobic cells	[PMID: 9873426]
V79	IC₅₀	17 μM Compound: 4	Antiproliferative activity against chinese hamster V79 NTRpuro cells after 18 hrs Antiproliferative activity against chinese hamster V79 NTRpuro cells after 18 hrs	[PMID: 17326614]
V79	IC₅₀	490 μM Compound: 4	Antiproliferative activity against chinese hamster wild-type V79 NTR-ve cells after 18 hrs Antiproliferative activity against chinese hamster wild-type V79 NTR-ve cells after 18 hrs	[PMID: 17326614]
WiDr	IC₅₀	703 μM Compound: 4	Antiproliferative activity against human wild type WiDr NTR-ve cells after 18 hrs Antiproliferative activity against human wild type WiDr NTR-ve cells after 18 hrs	[PMID: 17326614]
WiDr	IC₅₀	9.5 μM Compound: 4	Antiproliferative activity against human WiDr NTRneo cells after 18 hrs Antiproliferative activity against human WiDr NTRneo cells after 18 hrs	[PMID: 17326614]

Chemical Information

No. CAS 142439-61-0
Peso molecular 351.14
Fòrmula C₁₁H₁₂Cl₂N₄O₅
SMILES

O=C(C1=CC(N(CCCl)CCCl)=C(C=C1[N+]([O-])=O)[N+]([O-])=O)N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Çelik A, et al. An unusually cold active nitroreductase for prodrug activations. Bioorg Med Chem. 2012 Jun 1;20(11):3540-50. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto