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Referencia número: HY-122681

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SR-16434

(Synonyms: SR-16435 free base)

SR-16434 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor K_i=7.49; μ-Opioid receptor K_i=2.70). SR-16434 can relieve pain.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 857262-16-9
Fòrmula: C₂₂H₃₀N₂O
Peso molecular:338.49

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SR-16434 Chemical Structure

No. CAS: 857262-16-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

NOP receptor

7.49 (Ki)

μ-opioid

2.70 (Ki)

κ-opioid

219.47 (Ki)

Ver todos los productos específicos de isoformas Opioid Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	28.7 nM Compound: 2	Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis	[PMID: 23623415]
CHO	EC₅₀	29 nM Compound: 2	Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis	[PMID: 23623415]
CHO	EC₅₀	<10000 nM Compound: 2	Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis	[PMID: 23623415]

In Vivo

SR 16434 (10, 30 mg/kg; s.c.; single-dose) produces dose-dependent increase in tail-flick latency and induces antinociception^[1].
SR 16434 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

20 to 25 g male ICR mice^[1]
Dosage:

10, 30 mg/kg
Administration:

s.c. for single-dose
Result:

Produced dose-dependent increase in tail-flick latency and induced antinociception.

Animal Model:

20 to 25 g male ICR mice^[1]
Dosage:

10, 30 mg/kg
Administration:

s.c. once daily for 9 days
Result:

Produced an increase in tail-lick latency across days, induced conditioned place preference, and decreased global activity.

Chemical Information

No. CAS 857262-16-9
Peso molecular 338.49
Fòrmula C₂₂H₃₀N₂O
SMILES

O=C1N(C2CCN(C3C4CCCC3CCC4)CC2)C5=C(C=CC=C5)C1
Synonyms

SR-16435 free base
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Khroyan TV, et al. SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice. J Pharmacol Exp Ther. 2007;320(2):934-943. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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SR-16434

Ver todos los productos específicos de isoformas Opioid Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SR-16434 Related Classifications

HY-122681 Related Classifications