STK189682
STK189682 is an ATPase inhibitor targeting MDA5, LGP2 and DDX1, with IC50 values of 7 μM, 7 μM and 5 μM, respectively. STK189682 binds to the MDA5-ATP complex in an ATP-noncompetitive manner and does not compete with RNA.
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- No. CAS: 765922-18-7
- Fòrmula: C21H16N4O4S2
- Peso molecular:452.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
STK189682 potently inhibits the ATPase activities of recombinant MDA5 (IC50 = 7 μM), LGP2 (IC50 = 7 μM) and DDX1 (IC50 = 5 μM)[1].
STK189682 is an ATP-uncompetitive inhibitor of recombinant MDA5, which is evidenced by the observation that its IC50 value decreases as ATP concentration increases[1].
STK189682 does not compete with RNA for binding to recombinant MDA5, as the IC50 value remains unchanged with increasing RNA concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 765922-18-7
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Peso molecular 452.51
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Fòrmula C21H16N4O4S2
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SMILES
O=C(C1=CC=C(NC2=NC(C3=C(C)N=C(NC(C4=CC=CC=C4)=O)S3)=CS2)C=C1O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STK189682 Related Classifications
HY-187308 Related Classifications
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