TP-030-1
TP-030-1, a chemical probe, is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2095514-75-1
- Fòrmula: C23H22N4O3
- Peso molecular:402.45
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
18 nM
Compound: 14
|
Induction of necroptosis in human HT-29 cells assessed as increase in TNFalpha/AT-406/zVAD-FMK-induced LDH release preincubated with cells followed by TNFalpha/AT-406/zVAD-FMK addition measured after 16 to 20 hrs by CytoTox 96 nonradioactive cytotoxicity
Induction of necroptosis in human HT-29 cells assessed as increase in TNFalpha/AT-406/zVAD-FMK-induced LDH release preincubated with cells followed by TNFalpha/AT-406/zVAD-FMK addition measured after 16 to 20 hrs by CytoTox 96 nonradioactive cytotoxicity
|
[PMID: 29485864] |
TP-030-1 inhibits HT29 necroptosis with an IC50 value of 18 nM[1]. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM[1]. TP-030-1 inhibits mRIPK1 with an IC50 value of 4.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 2095514-75-1
-
Peso molecular 402.45
-
Fòrmula C23H22N4O3
-
SMILES
O=C1[C@@H](N2CCC3=CN(CC4=CC=CC=C4)N=C3C2=O)COC5=CC=CC=C5N1C
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TP-030-1 Related Classifications
HY-148253 Related Classifications
Powered by Bioz