TRIM
Based on 1 Customer Validation
TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.80%
- No. CAS: 25371-96-4
- Fòrmula: C10H7F3N2
- Peso molecular:212.17
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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L-NMMA acetate -
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L-NIL -
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Nω-Propyl-L-arginine -
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ARL 17477
Actividad biológica
Descripciòn
IC50 & Target
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iNOS |
nNOS |
In Vitro
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 25371-96-4
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Appearance Solid
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Peso molecular 212.17
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Fòrmula C10H7F3N2
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Color White to off-white
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SMILES
FC(C1=CC=CC=C1N2C=CN=C2)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
In Vitro:
DMSO : 250 mg/mL (1178.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Handy RL, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116(5):2349-2350. [Content Brief]
[2]. Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res. 2003;140(1-2):141-147. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7132 mL | 23.5660 mL | 47.1320 mL | 117.8300 mL |
| 5 mM | 0.9426 mL | 4.7132 mL | 9.4264 mL | 23.5660 mL | |
| 10 mM | 0.4713 mL | 2.3566 mL | 4.7132 mL | 11.7830 mL | |
| 15 mM | 0.3142 mL | 1.5711 mL | 3.1421 mL | 7.8553 mL | |
| 20 mM | 0.2357 mL | 1.1783 mL | 2.3566 mL | 5.8915 mL | |
| 25 mM | 0.1885 mL | 0.9426 mL | 1.8853 mL | 4.7132 mL | |
| 30 mM | 0.1571 mL | 0.7855 mL | 1.5711 mL | 3.9277 mL | |
| 40 mM | 0.1178 mL | 0.5892 mL | 1.1783 mL | 2.9458 mL | |
| 50 mM | 0.0943 mL | 0.4713 mL | 0.9426 mL | 2.3566 mL | |
| 60 mM | 0.0786 mL | 0.3928 mL | 0.7855 mL | 1.9638 mL | |
| 80 mM | 0.0589 mL | 0.2946 mL | 0.5892 mL | 1.4729 mL | |
| 100 mM | 0.0471 mL | 0.2357 mL | 0.4713 mL | 1.1783 mL |
TRIM Related Classifications
HY-101316 Related Classifications
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