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Referencia número: HY-N19903

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Verticilatin

Verticilatin is a prenylated diaryl ether derived from phytopathogenic fungi, acting as an antibacterial agent and biofilm inhibitor. Verticilatin exhibits no direct growth inhibitory activity against Gram-negative bacteria. Verticilatin effectively inhibits the growth of Gram-positive strains, including methicillin-sensitive/resistant Staphylococcus aureus and Enterococcus faecalis, and reduces the biofilm-forming ability of Gram-negative Stenotrophomonas maltophilia. Verticilatin can be used for infections caused by the aforementioned Gram-positive bacteria and biofilm infections caused by Stenotrophomonas maltophilia.

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No. CAS: 2243140-21-6
Fòrmula: C₁₉H₂₂O₃
Peso molecular:298.38

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Verticilatin Chemical Structure

No. CAS: 2243140-21-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

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In Vitro

Verticilatin (4 mg/L) does not inhibit growth of Gram-negative bacteria, reduces biofilm formation in two Stenotrophomonas maltophilia strains by up to 63%, and potently inhibits growth of Gram-positive MSSA, MRSA, and Enterococcus faecalis strains with an MIC of 4 mg/L^[1].
Verticilatin (2a) (4 mg/L; 24 h) potently inhibits the growth of MSSA ATCC25923, MRSA GK2235, MRSA USA300, and Enterococcus faecalis ATCC29212 with an MIC of 4 mg/L for all tested strains^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2243140-21-6
Peso molecular 298.38
Fòrmula C₁₉H₂₂O₃
SMILES

OC1=CC(C)=CC(OC2=CC(C)=C(C/C=C(C)\C)C(O)=C2)=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Staphylococcus aureus
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Boehlich G J. Synthesis of Diorcinols and C-acyl glycosidic compounds[D]. Staats-und Universitätsbibliothek Hamburg Carl von Ossietzky, 2022.

[2]. Boehlich GJ, et al. Total Synthesis of Anti-MRSA Active Diorcinols and Analogues. Chemistry (Weinheim an der Bergstrasse, Germany). 2020 Aug 06;26(44):9846-9850. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Verticilatin

Ver todos los productos específicos de isoformas Antibiotic