VHLL-BCN
Based on 1 Customer Validation
VHLL-BCN is a ligand targeting the VHL E3 ligase, which can be used for the synthesis of PROTAC molecules. As a key component of the copper-free SPAAC-based rapid synthesis platform for transcription factor PROTACs, VHLL-BCN is applicable to cancer-related research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 95.06%
- No. CAS: 2874203-49-1
- Fòrmula: C35H45N5O6S
- Peso molecular:663.83
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
VHLL-BCN undergoes copper-free SPAAC with azide-modified NF-κB-targeting DNA oligomer under physiological conditions to form a TF-PROTAC that reduces p65 protein levels in cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2874203-49-1
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Appearance Solid
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Peso molecular 663.83
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Fòrmula C35H45N5O6S
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Color White to off-white
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SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CNC(OC[C@@H]4[C@@]5([H])[C@]4([H])CCC#CCC5)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 8.33 mg/mL (12.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[3]. Zhu Z, et al. (GGAA)3-Based TF-PROTACs Enable Targeted Degradation of ETV6 to Inhibit Ewing Sarcoma Growth. J Am Chem Soc. 2025;147(16):13396-13404. [Content Brief]
[4]. Rodrigues DA, et al. Fulfilling multiple roles in PROTAC design: The emerging potential of oligonucleotides. Eur J Med Chem. 2026;307:118688. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5064 mL | 7.5320 mL | 15.0641 mL | 37.6602 mL |
| 5 mM | 0.3013 mL | 1.5064 mL | 3.0128 mL | 7.5320 mL | |
| 10 mM | 0.1506 mL | 0.7532 mL | 1.5064 mL | 3.7660 mL |
VHLL-BCN Related Classifications
HY-148880 Related Classifications
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