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Referencia número: HY-119772

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VU0366369

Name: VU0366369
Brand: MedChemExpress
SKU: HY-119772
Price: 59.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ML137)

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VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC₅₀ of 830 nM. VU0366369 can be used in research about central nervous system diseases.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1222834-53-8
Fòrmula: C₁₉H₁₄FN₃O₂
Peso molecular:335.33

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

VU0366369 Chemical Structure

No. CAS: 1222834-53-8

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC₅₀ of 830 nM. VU0366369 can be used in research about central nervous system diseases^[1].

IC₅₀ & Target

EC₅₀: 830 nM (mAChR M1)

Ver todos los productos específicos de isoformas Cholinesterase (ChE) :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.83 μM Compound: 12a, VU0366369	Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay	[PMID: 20156687]
CHO-K1	EC₅₀	830 nM Compound: 2, ML 137	Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay	[PMID: 25435150]

Chemical Information

No. CAS 1222834-53-8
Peso molecular 335.33
Fòrmula C₁₉H₁₄FN₃O₂
SMILES

O=C1C(N(CC2=C(F)C=C(C3=CN(C)N=C3)C=C2)C4=C1C=CC=C4)=O
Synonyms

ML137
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Bridges TM, et al., Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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VU0366369

Ver todos los productos específicos de isoformas Cholinesterase (ChE)