VU0415248
VU0415248 is a selective muscarinic acetylcholine receptor 1 (M1) inhibitor. VU0415248 inhibits acetylcholine-induced calcium mobilization in cells expressing human and rat M1 muscarinic acetylcholine receptors, with an IC50 of 0.4 and 0.18 μM, respectively. VU0415248 is applicable to the research of Parkinson's disease, movement disorders and fragile X syndrome.
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- No. CAS: 1359087-83-4
- Fòrmula: C21H23N5O3S
- Peso molecular:425.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
mAChR1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.18 μM
Compound: 13l, VU0415248
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Antagonist activity at rat muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by fluorescence assay
Antagonist activity at rat muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by fluorescence assay
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[PMID: 22197142] |
In Vitro
VU0415248 inhibits acetylcholine-induced calcium mobilization in human M1 muscarinic acetylcholine receptor-expressing cells with an IC50 of 0.4 μM[1].
VU0415248 (30 μM) inhibits acetylcholine-induced calcium mobilization in rat M1 muscarinic acetylcholine receptor-expressing cells with an IC50 of 0.18 μM, and shows very high selectivity over rat and human M2-5 muscarinic acetylcholine receptors (human M2-5 IC50 > 30 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1359087-83-4
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Peso molecular 425.50
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Fòrmula C21H23N5O3S
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SMILES
O=C(CCNS(=O)(C1=CC=CC2=NC=CC=C21)=O)N3CCN(CC3)C4=CC=NC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU0415248 Related Classifications
HY-182587 Related Classifications
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Keywords
- VU0415248
- 1359087-83-4
- VU 0415248
- VU-0415248
- mAChR
- human M1 muscarinic acetylcholine receptor-expressing cells
- acetylcholine-induced calcium mobilization
- M1
- muscarinic acetylcholine receptor 1
- rat M1 muscarinic acetylcholine receptor-expressing cells
- fragile x syndrome
- parkinson’s disease
- human M2-M5 muscarinic receptor subtypes
- movement disorders
- rat M2-M5 muscarinic receptor subtypes
- Inhibitor
- inhibitor
- inhibit