IL24 - interleukin 24 Gene

Also Known as C49A; FISP; MDA7; MOB5; ST16; IL10B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11009

About IL24

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,897,443-206,904,139 (from NCBI)

This gene has 7 transcripts (splice variants), 158 orthologues and 4 paralogues. Biased expression in lymph node (RPKM 12.3), spleen (RPKM 9.6) and 6 other tissues.

Summary

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce Apoptosis selectively in various Cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of Apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL24 Products (4)

mRNA	Protein	Name
NM_001185156.1	NP_001172085.1	interleukin-24 isoform 3 precursor
NM_001185157.1	NP_001172086.1	interleukin-24 isoform 4 precursor
NM_001185158.1	NP_001172087.1	interleukin-24 isoform 5
NM_006850.3	NP_006841.1	interleukin-24 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25640309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-24	IL-4-induced secreted protein

IL24 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL24	Q13007	RAD51	Homo sapiens	Q06609	Y2H Array	25640309
Intra	IL24	Q13007	RAD51	Homo sapiens	Q06609	Anti Tag CoIP	25640309
Intra	IL24	Q13007	PARP1	Homo sapiens	P09874	Y2H Array	25640309
Intra	IL24	Q13007	PARP1	Homo sapiens	P09874	Anti Tag CoIP	25640309

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL24 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77003	IL-24 Protein, Human (HEK293, His)	Q13007-2/NP_001172085.1 (Q53-L207)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77004	IL-24 Protein, Human (HEK293, Fc)	Q13007-2 (Q53-L207)	≥ 80%, as determined by reducing SDS-PAGE.
HY-P700115AF	Animal-Free IL-24 Protein, Human (His)	Q13007-1 (Q52-L206)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Psoriasis
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Fungal Esophagitis
Chronic Inducible Urticaria
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Facial Hemiatrophy	Parry-Romberg Syndrome
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06743	IL24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174615	Human IL24 mRNA		/	Unkown
HY-RS17746	Il24 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24212	Il24 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990016	Temtokibart	Inhibitor	99.23%	Unkown
HY-P992243	Anti-IL-24 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IL24	VGNC	VGNC:30148
Canis familiaris	IL24	VGNC	VGNC:41974
Rattus norvegicus	IL24	RGD	RGD:621484
Felis catus	IL24	VGNC	VGNC:107884
Mus musculus	IL24	MGD	MGI:2135548
Macaca mulatta	IL24	VGNC	VGNC:99981
Others	IL24	NCBI