CD300A - CD300a molecule Gene

Also Known as IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11314

About CD300A

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,466,373-74,484,798 (from NCBI)

This gene has 7 transcripts (splice variants), 91 orthologues and 13 paralogues. Broad expression in spleen (RPKM 24.5), appendix (RPKM 12.1) and 14 other tissues.

Summary

This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the Other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

CD300A Products (4)

mRNA Protein Name
NM_001256841.2 NP_001243770.1 CMRF35-like molecule 8 isoform 2 precursor
NM_001330456.1 NP_001317385.1 CMRF35-like molecule 8 isoform 3
NM_001330457.2 NP_001317386.1 CMRF35-like molecule 8 isoform 4 precursor
NM_007261.4 NP_009192.2 CMRF35-like molecule 8 isoform 1 precursor

CD300A Protein Structure

V-set

V-set: Immunoglobulin V-set domain (19 - 112)

SIT

SIT: SHP2-interacting transmembrane adaptor protein, SIT (181 - 275)

  • 0
  • 100
  • 200
  • 299 a.a.
Protein Preferred Names Protein Names

CMRF35-like molecule 8

  • CD300 antigen-like family member A

CD300A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD300A Q9UGN4 KRT38 Homo sapiens O76015
Y2H Array
25416956
Intra
CD300A Q9UGN4 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
Intra
CD300A Q9UGN4 CD300LB Homo sapiens A8K4G0
Anti Tag CoIP
20959446
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD300A Proteins

Cat. No. Product Name Accession Purity
HY-P70754 CD300a/LMIR1 Protein, Human (HEK293, Fc-His) Q9UGN4-1 (L18-Q178) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72738 CD300a/LMIR1 Protein, Human (HEK293, His) Q9UGN4-1 (L18-Q178) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02226 CD300A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19052 Cd300a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25542 Cd300a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992207 Anti-CD300A Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CD300A RGD RGD:1583719
Macaca mulatta CD300A VGNC VGNC:104592
Mus musculus CD300A MGD MGI:2443411
Others CD300A NCBI