Map3k8 - mitogen-activated protein kinase kinase kinase 8 Gene

Rattus norvegicus

Also known as Tpl2; Tpl-2; D17TPL2

Gene ID: 116596 | Gene type: protein coding

About Map3k8

Primary_assembly 17: 53,383,131-53,403,216 forward strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 199 orthologues, 36 paralogues and is associated with 23 phenotypes. Biased expression in Spleen (RPKM 18.2), Lung (RPKM 65.) and 8 other tissues.

Summary

Enables MAP kinase kinase kinase activity. Predicted to be involved in MAPK cascade; immune system process; and protein phosphorylation. Predicted to be located in cytosol. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Map3k8 Products(1)

mRNA	Protein	Name
NM_053847.2	NP_446299.2	mitogen-activated protein kinase kinase kinase 8

Map3k8 Protein Structure

STKc_MAP3K8

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 8

serine/threonine kinase (Tpl-2)

tumor progression locus 2

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12358	Tpl2 Kinase Inhibitor 1	Inhibitor	99.22%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k8	NCBI	NCBI:1326