MAP3K8 - mitogen-activated protein kinase kinase kinase 8 Gene

Homo sapiens

Also known as COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT

Gene ID: 1326 | Gene type: protein coding

About MAP3K8

Cytogenetic location: 10p11.23 Genomic coordinates (GRCh38): 10:30,434,021-30,461,833 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 18.4), appendix (RPKM 6.8) and 17 other tissues.

Summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

MAP3K8 Products(9)

mRNA	Protein	Name
XM_017015714.2	XP_016871203.1	mitogen-activated protein kinase kinase kinase 8 isoform X2
XM_017015710.1	XP_016871199.1	mitogen-activated protein kinase kinase kinase 8 isoform X1
XM_047424623.1	XP_047280579.1	mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_005204.4	NP_005195.2	mitogen-activated protein kinase kinase kinase 8
XM_047424622.1	XP_047280578.1	mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_001320961.2	NP_001307890.1	mitogen-activated protein kinase kinase kinase 8
XM_017015709.3	XP_016871198.1	mitogen-activated protein kinase kinase kinase 8 isoform X1
XM_047424624.1	XP_047280580.1	mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_001244134.1	NP_001231063.1	mitogen-activated protein kinase kinase kinase 8

MAP3K8 Protein Structure

Pkinase

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 8

Ewing sarcoma transformant	augmented in rheumatoid arthritis 2
cot (cancer Osaka thyroid) oncogene	proto-oncogene c-Cot
proto-oncogene serine/threoine protein kinase	tumor progression locus 2

Recombinant MAP3K8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75921	MAP3K8/TPL-2 Protein, Human (sf9, GST)	P41279 (M30-R397)	≥95%

Related Diseases

Diseases

Alias

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Ewings Sarcoma	Ewing'S Sarcoma
Peripheral Neuroepithelioma	Primitive Neuroectodermal Tumor
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Extraosseous Ewing Tumor	Askin Tumor
Ewing'S Family Localized Tumor	Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing Sarcoma	Localized Ewing'S Sarcoma
Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing'S Tumor
Pnet Of Thoracopulmonary Region	Ewing Family Of Tumors
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Spitzoid Melanoma

Atypical Spitz Nevus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12358	Tpl2 Kinase Inhibitor 1	Inhibitor	99.22%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAP3K8	VGNC	VGNC:97497
Bos taurus	MAP3K8	VGNC	VGNC:31202
Canis familiaris	MAP3K8	VGNC	VGNC:42979
Rattus norvegicus	MAP3K8	RGD	RGD:620969
Mus musculus	MAP3K8	MGD	MGI:1346878
Macaca mulatta	MAP3K8	VGNC	VGNC:81464
Others	MAP3K8	NCBI