Sv2a - synaptic vesicle glycoprotein 2a Gene

Also Known as Sv2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117559

Summary

Predicted to enable protein kinase binding activity. Involved in regulation of gamma-aminobutyric acid secretion. Located in several cellular components, including neuronal cell body; presynaptic active zone; and synaptic vesicle membrane. Is integral component of membrane. Is integral component of synaptic vesicle membrane. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A). [provided by Alliance of Genome Resources, Apr 2022]

Sv2a Products (1)

mRNA Protein Name
NM_057210.3 NP_476558.2 synaptic vesicle glycoprotein 2A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8910372 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
27265781 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
27265781 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
27265781 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
22875941 RGD
located in synapse IDA
IDA: Inferred from direct assay
10712642 RGD
is active in synaptic vesicle membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23622064 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
1519064 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptic vesicle glycoprotein 2A

  • synaptic vesicle protein 2

  • synaptic vesicle protein 2A

  • synaptic vesicle transmembrane transporter (SV2) RNA

Sv2a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sv2a Q02563 Syt1 Rattus norvegicus P21707
Pull Down
8910372
Cross
Sv2a Q02563 botA Clostridium botulinum P0DPI0
Pull Down
24583011
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0106 Levetiracetam Inhibitor 99.98% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-119810 Seletracetam Modulator 99.70% Phase 3
HY-119810B Seletracetam lithium bromide Modulator / Phase 3
HY-136873 UCB-J Ligand 99.62% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157999 SDI-118 Modulator 98.86% Unkown
HY-167830 SDM-8 99.79% Unkown
HY-180554 UCB1244283 Modulator / Unkown
HY-136873A (Rac)-UCB-J Ligand / Unkown
HY-176866 Rodin-A Inhibitor / Unkown
HY-176867 Rodin-B Inhibitor / Unkown
HY-B0106S Levetiracetam-d6 Inhibitor / Unkown
HY-RS14054 SV2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0106S1 Levetiracetam-d3 Inhibitor / Unkown
HY-RS16880 Sv2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23322 Sv2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119810A Seletracetam lithium / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sv2a NCBI NCBI:9900