Arnt - aryl hydrocarbon receptor nuclear translocator Gene

Also Known as Drnt; Hif1b; ESTM42; bHLHe2; mKIAA4051; D3Ertd557e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11863

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor activity; and protein heterodimerization activity. Involved in positive regulation of protein sumoylation. Acts upstream of or within several processes, including embryonic placenta development; positive regulation of transcription by RNA polymerase II; and response to hypoxia. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human ARNT (Aryl Hydrocarbon Receptor nuclear translocator). [provided by Alliance of Genome Resources, Apr 2022]

Arnt Products (7)

mRNA Protein Name
NM_001037737.2 NP_001032826.1 aryl hydrocarbon receptor nuclear translocator isoform a
NM_001409517.1 NP_001396446.1 aryl hydrocarbon receptor nuclear translocator isoform c
NM_001409518.1 NP_001396447.1 aryl hydrocarbon receptor nuclear translocator isoform d
NM_001409519.1 NP_001396448.1 aryl hydrocarbon receptor nuclear translocator isoform e
NM_001409520.1 NP_001396449.1 aryl hydrocarbon receptor nuclear translocator isoform f
NM_001409522.1 NP_001396451.1 aryl hydrocarbon receptor nuclear translocator isoform g
NM_009709.4 NP_033839.2 aryl hydrocarbon receptor nuclear translocator isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15363889 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
9000051 MGI
contributes to nuclear receptor activity IMP
IMP: Inferred from mutant phenotype
11043581 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8702901 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
24001774 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
26245371 MGI
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28602820 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
16287860 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
16287860 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15363889 MGI
involved in positive regulation of protein sumoylation IDA
IDA: Inferred from direct assay
19251700 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
9000051 MGI
acts upstream of or within response to hypoxia IDA
IDA: Inferred from direct assay
8702901 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11025203 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11025203 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9000051 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aryl hydrocarbon receptor nuclear translocator

  • HIF-1-beta

  • HIF1-beta

  • dioxin receptor, nuclear translocator

  • hypoxia-inducible factor 1-beta

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16031A AFP464 / Phase 2
HY-183117 NEO-811 Degrader / Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120087 KG-548 Inhibitor 99.90% Unkown
HY-D0932 Sudan IV 98.0% Unkown
HY-19621 THS-044 Modulator 99.67% Unkown
HY-159644 Casdatifan 96.37% Unkown
HY-112374 NPAS3-IN-1 Inhibitor 98.72% Unkown
HY-RS01011 ARNT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W012248 KG-655 Inhibitor 99.87% Unkown
HY-183583 HIF-2α-IN-18 Inhibitor / Unkown
HY-186020 L-4-Aminoarabinose-bactoprenyl phosphate / Unkown
HY-RS01012 ARNT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08421 MIA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-D0932S Sudan IV-d6 / Unkown
HY-RS18908 Arnt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25399 Arnt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arnt NCBI NCBI:405