SFXN2 - sideroflexin 2 Gene

Also Known as SLC56A2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 118980

About SFXN2

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,714,636-102,743,492 (from NCBI)

This gene has 13 transcripts (splice variants), 205 orthologues and 4 paralogues. Broad expression in kidney (RPKM 25.3), thyroid (RPKM 4.8) and 16 other tissues.

Summary

Predicted to enable serine transmembrane transporter activity. Involved in mitochondrial transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SFXN2 Products (2)

mRNA Protein Name
NM_001350989.2 NP_001337918.1 sideroflexin-2
NM_178858.6 NP_849189.1 sideroflexin-2

SFXN2 Protein Structure

Mtc

Mtc: Tricarboxylate carrier (15 - 322)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
Protein Preferred Names Protein Names

sideroflexin-2

SFXN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SFXN2 Q96NB2 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SFXN2 Q96NB2 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SFXN2 Q96NB2 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
SFXN2 Q96NB2 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
SFXN2 Q96NB2 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
SFXN2 Q96NB2 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
SFXN2 Q96NB2 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
SFXN2 Q96NB2 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
SFXN2 Q96NB2 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
SFXN2 Q96NB2 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
SFXN2 Q96NB2 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
SFXN2 Q96NB2 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 18

  • Growth And Developmental Delay-Hypotonia-Vision Impairment-Lactic Acidosis Syndrome

  • COXPD18

  • Combined Oxidative Phosphorylation Deficiency, Type 18
Combined Oxidative Phosphorylation Deficiency 7

  • COXPD7

  • Combined Oxidative Phosphorylation Defect Type 7

  • Severe C12orf65-Related Combined Oxidative Phosphorylation Defect

  • Severe C12orf65-Related Coxpd

  • Combined Oxidative Phosphorylation Deficiency, Type 7
Sengers Syndrome

  • Mitochondrial Dna Depletion Syndrome 10

  • Cardiomyopathy And Cataract

  • Cataract And Cardiomyopathy

  • MTDPS10

  • Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

  • Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

  • Senger Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12786 SFXN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SFXN2 MGD MGI:2137678
Bos taurus SFXN2 VGNC VGNC:34531
Rattus norvegicus SFXN2 RGD RGD:1306131
Felis catus SFXN2 VGNC VGNC:65070
Canis familiaris SFXN2 VGNC VGNC:46088
Others SFXN2 NCBI