B2m - beta-2 microglobulin Gene

Also Known as Ly-m11; beta2m; beta2-m

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12010

Summary

Predicted to enable MHC class II protein complex binding activity and protein homodimerization activity. Involved in learning or memory; modulation of age-related behavioral decline; and negative regulation of cell differentiation. Acts upstream of or within several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cellular response to iron(III) ion; and protein refolding. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study hemochromatosis and Type 1 Diabetes mellitus. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; immunodeficiency 43; and Inflammatory Bowel Disease. Orthologous to human B2M (beta-2-microglobulin). [provided by Alliance of Genome Resources, Apr 2022]

B2m Products (1)

mRNA Protein Name
NM_009735.3 NP_033865.2 beta-2-microglobulin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14735325 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell differentiation in thymus IGI
IGI: Inferred from genetic interaction
18776904 MGI
acts upstream of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16299293 MGI
acts upstream of or within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
IMP: Inferred from mutant phenotype
16299293 MGI
acts upstream of or within cellular response to iron(III) ion IMP
IMP: Inferred from mutant phenotype
9531620 MGI
acts upstream of or within iron ion transport IMP
IMP: Inferred from mutant phenotype
9531620 MGI
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
26147761 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
11113132 MGI
involved in negative regulation of forebrain neuron differentiation IMP
IMP: Inferred from mutant phenotype
26147761 MGI
involved in negative regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
26147761 MGI
acts upstream of or within negative regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
20018625 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16299293 MGI
acts upstream of or within protein refolding IDA
IDA: Inferred from direct assay
16920948 MGI
acts upstream of or within regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9531620 MGI
acts upstream of or within response to molecule of bacterial origin IMP
IMP: Inferred from mutant phenotype
16299293 MGI
involved in sensory perception of smell IMP
IMP: Inferred from mutant phenotype
10912502 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
1538753 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-2-microglobulin

Recombinant B2m Proteins

Cat. No. Product Name Accession Purity
HY-P70656 FCGRT-B2M Heterodimer Protein, Mouse (HEK293, His) Q61559 (S22-V301)&P01887 (I21-M119) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74403 B2M/Beta-2 microglobulin Protein, Mouse (HEK293, His) P01887 (I21-M119, A105D) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75199 FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, A105D, HEK293, His-Avi) Q61559 (S22-S297)&P01887 (A21-M119, A105D) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75200 FCGRT-B2M Heterodimer Protein, Mouse (Biotinylated, HEK293, His) Q61559 (S22-S297)&P01887 (A21-M119) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76778 CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His) P11609 (Q22-W297)&P01887 (I21-M119) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76779 CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His) P11610 (Q22-G305)&P01887 (I21-M119) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78240 B2M/Beta-2 microglobulin Protein, Mouse (HEK293, Fc) P01887 (I21-M119) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01299 B2M Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16933 B2m Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23376 B2m Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens B2m NCBI NCBI:567