Socs3 - suppressor of cytokine signaling 3 Gene

Also Known as Cis3; Ef10; Ssi3; Cish3; EF-10; SSI-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12702

Summary

Enables phosphotyrosine residue binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of Insulin Receptor signaling pathway; and placenta development. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Apr 2022]

Socs3 Products (1)

mRNA Protein Name
NM_007707.3 NP_031733.1 suppressor of cytokine signaling 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables miRNA binding IDA
IDA: Inferred from direct assay
30294880 MGI
enables miRNA binding IMP
IMP: Inferred from mutant phenotype
30294880 MGI
enables phosphotyrosine residue binding IMP
IMP: Inferred from mutant phenotype
16302975 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15169905 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching involved in labyrinthine layer morphogenesis IMP
IMP: Inferred from mutant phenotype
11481489 MGI
acts upstream of cell differentiation IDA
IDA: Inferred from direct assay
15358627 MGI
acts upstream of cell differentiation IGI
IGI: Inferred from genetic interaction
15358627 MGI
involved in cellular response to interleukin-17 IDA
IDA: Inferred from direct assay
30294880 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
20530874 MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
15169905 MGI
acts upstream of or within negative regulation of signal transduction IGI
IGI: Inferred from genetic interaction
15358627 MGI
acts upstream of or within placenta blood vessel development IMP
IMP: Inferred from mutant phenotype
11481489 MGI
acts upstream of or within positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
15358627 MGI
acts upstream of or within positive regulation of cell differentiation IGI
IGI: Inferred from genetic interaction
15358627 MGI
acts upstream of or within regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15169905 MGI
acts upstream of signal transduction IGI
IGI: Inferred from genetic interaction
15358627 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

suppressor of cytokine signaling 3

  • CIS-3

  • E2a-Pbx1 target gene in fibroblasts 10

  • STAT-induced STAT inhibitor 3

  • cytokine inducible SH2-containing protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0444 Rubiadin 99.20% Unkown
HY-155335 FPR2 agonist 3 Agonist 99.39% Unkown
HY-RS16260 Socs3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117511 HJC0123 99.06% Unkown
HY-169908 STAT3-IN-37 Inhibitor / Unkown
HY-RS13554 SOCS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124595 MPT0B098 Inhibitor / Unkown
HY-183519 AH057 Inhibitor / Unkown
HY-RS23359 Socs3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990001 Anti-Mouse IL-10 Antibody (JES5-2A5) Inhibitor 98.666% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Socs3 NCBI NCBI:9021