2. Gene
  3. Dbh - dopamine beta hydroxylase Gene

Dbh - dopamine beta hydroxylase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 13166 | Gene type: protein coding

About Dbh

Chromosome 2: 27,055,245-27,073,212 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 200 orthologues, 2 paralogues and is associated with 22 phenotypes. Restricted expression toward adrenal adult (RPKM 151.1).

Summary

Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Involved in Catecholamine metabolic process; locomotory behavior; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including behavioral response to ethanol; homoiothermy; and learning or memory. Located in secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Dbh Products(1)

mRNA Protein Name
NM_138942.3 NP_620392.2 dopamine beta-hydroxylase

Dbh Protein Structure

DOMON

DOMON: pfam03351 (60 - 175)

Cu2_monooxygen

Cu2_monooxygen: pfam01082 (217 - 343)

Cu2_monoox_C

Cu2_monoox_C: pfam03712 (363 - 519)

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  • 622 a.a.
Protein Preferred Names Protein Names

dopamine beta-hydroxylase

dopamine beta-monooxygenase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106004 Zamicastat Inhibitor ≥98.0% Phase 2
HY-14838 Etamicastat Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N7204 4-Hydroxyderricin Inhibitor 99.97% Unkown
HY-14838A Etamicastat hydrochloride Inhibitor 98.14% Unkown
HY-RS03544 DBH Human Pre-designed siRNA Set A / Unkown
HY-RS03545 Dbh Mouse Pre-designed siRNA Set A / Unkown
HY-RS03546 Dbh Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dbh NCBI NCBI:1621