Dbh - dopamine beta hydroxylase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13166

About Dbh

Chromosome 2: 27,055,245-27,073,212 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 200 orthologues, 2 paralogues and is associated with 22 phenotypes. Restricted expression toward adrenal adult (RPKM 151.1).

Summary

Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Involved in Catecholamine metabolic process; locomotory behavior; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including behavioral response to ethanol; homoiothermy; and learning or memory. Located in secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Dbh Products (1)

mRNA Protein Name
NM_138942.3 NP_620392.2 dopamine beta-hydroxylase

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
9189272 MGI
acts upstream of or within behavioral response to ethanol IMP
IMP: Inferred from mutant phenotype
10777779 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
15231500 MGI
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
10051631 MGI
acts upstream of or within dopamine catabolic process IMP
IMP: Inferred from mutant phenotype
10051631 MGI
involved in dopamine catabolic process IMP
IMP: Inferred from mutant phenotype
7715704 MGI
acts upstream of or within fear response IMP
IMP: Inferred from mutant phenotype
15066288 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
12959968 MGI
acts upstream of or within homoiothermy IMP
IMP: Inferred from mutant phenotype
9139828 MGI
acts upstream of or within leukocyte mediated immunity IMP
IMP: Inferred from mutant phenotype
10051631 MGI
acts upstream of or within leukocyte migration IMP
IMP: Inferred from mutant phenotype
15849236 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
9189272 MGI
involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
27148966 MGI
acts upstream of or within maternal behavior IMP
IMP: Inferred from mutant phenotype
9393852 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
9189272 MGI
acts upstream of or within norepinephrine biosynthetic process IMP
IMP: Inferred from mutant phenotype
9603211 MGI
involved in norepinephrine biosynthetic process IMP
IMP: Inferred from mutant phenotype
7715704 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
9139828 MGI
acts upstream of or within positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
9139828 MGI
acts upstream of or within regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15849236 MGI
acts upstream of or within regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15849236 MGI
acts upstream of or within regulation of vascular endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15849236 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
12370425 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
11805341 MGI
acts upstream of vasoconstriction IMP
IMP: Inferred from mutant phenotype
9139828 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
9189272 MGI
Cellular Component GO Annotation Evidence References Source
located in secretory granule lumen IDA
IDA: Inferred from direct assay
7961964 MGI
located in secretory granule membrane IDA
IDA: Inferred from direct assay
7961964 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dbh Protein Structure

DOMON

DOMON: pfam03351 (60 - 175)

Cu2_monooxygen

Cu2_monooxygen: pfam01082 (217 - 343)

Cu2_monoox_C

Cu2_monoox_C: pfam03712 (363 - 519)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 622 a.a.
Protein Preferred Names Protein Names

dopamine beta-hydroxylase

  • dopamine beta-monooxygenase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-106004 Zamicastat Inhibitor 99.93% Phase 2
HY-14838 Etamicastat Inhibitor / Phase 2
HY-14838A Etamicastat hydrochloride Inhibitor 98.14% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N7204 4-Hydroxyderricin 99.79% Unkown
HY-RS03544 DBH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156989 Butobendine Inhibitor / Unkown
HY-RS03545 Dbh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03546 Dbh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dbh NCBI NCBI:1621