Dcc - deleted in colorectal carcinoma Gene

Also Known as Igdcc1; C030036D22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13176

Summary

Predicted to enable identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within generation of neurons. Located in axon. Is integral component of postsynaptic density membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Dcc Products (1)

mRNA Protein Name
NM_007831.3 NP_031857.2 netrin receptor DCC precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11527412 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axon guidance IMP
IMP: Inferred from mutant phenotype
18479186 MGI
acts upstream of or within dorsal/ventral axon guidance IMP
IMP: Inferred from mutant phenotype
17898206 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
16267219 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
23291093 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
23291093 MGI
acts upstream of or within spinal cord ventral commissure morphogenesis IMP
IMP: Inferred from mutant phenotype
9126737 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
23291093 MGI
is active in Schaffer collateral - CA1 synapse IEP
IEP: Inferred from expression pattern
23291093 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
23291093 MGI
located in axon IDA
IDA: Inferred from direct assay
9331350 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
23291093 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
23291093 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

netrin receptor DCC

  • tumor suppressor protein DCC

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112306 Ripretinib 98.90% Yes
HY-136256 Vimseltinib Inhibitor 99.94% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13024 Rebastinib 99.84% Phase 2
HY-160699 DCC-3116 Inhibitor 99.84% Phase 2
HY-B0791 Altiratinib Inhibitor 99.29% Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y1092 N,N-Dicyclohexylcarbodiimide(DCC) Activator 99.75% Unkown
HY-W074890 Palmitoylglycine Modulator 99.84% Unkown
HY-W099632 2-Hexyldecanoic acid 99.71% Unkown
HY-D2751 BP Fluor 488 cadaverine 98.15% Unkown
HY-100855 DC_C66 Inhibitor / Unkown
HY-13024A Rebastinib tosylate / Unkown
HY-163008 Dicamba-5-aminopentanoic acid / Unkown
HY-RS03571 DCC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-157262 Methyl isonicotinate-(CH2)2-COOH / Unkown
HY-D2764 Difluorocarboxyfluorescein cadaverine, 5-isomer / Unkown
HY-D2765 BP Fluor 405 cadaverine / Unkown
HY-D2772 5-TAMRA Cadaverine / Unkown
HY-RS17183 Dcc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23634 Dcc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dcc NCBI NCBI:1630