Dct - dopachrome tautomerase Gene

Also Known as DT; slt; TRP2; TRP-2; Tyrp2; slaty; Tyrp-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13190

Summary

Enables dopachrome isomerase activity. Involved in melanin biosynthetic process from tyrosine. Acts upstream of or within several processes, including developmental pigmentation; generation of neurons; and melanin biosynthetic process. Located in cytosol and melanosome. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; integumental system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase). [provided by Alliance of Genome Resources, Apr 2022]

Dct Products (1)

mRNA	Protein	Name
NM_010024.3	NP_034154.2	L-dopachrome tautomerase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables dopachrome isomerase activity	IDA IDA: Inferred from direct assay	2169885	MGI
enables dopachrome isomerase activity	IMP IMP: Inferred from mutant phenotype	1537334	MGI

Biological Process GO Annotation	Evidence	Referencias	Source
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	15060160	MGI
acts upstream of or within developmental pigmentation	IMP IMP: Inferred from mutant phenotype	15060160	MGI
acts upstream of or within melanin biosynthetic process	IMP IMP: Inferred from mutant phenotype	7665913	MGI
involved in melanin biosynthetic process from tyrosine	IDA IDA: Inferred from direct assay	2169885	MGI
involved in melanin biosynthetic process from tyrosine	IMP IMP: Inferred from mutant phenotype	33100333	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16857183	MGI
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	1537334	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16857183	MGI
acts upstream of or within ventricular zone neuroblast division	IMP IMP: Inferred from mutant phenotype	16857183	MGI

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21610032	MGI
located in cytosol	IDA IDA: Inferred from direct assay	2169885	MGI
located in melanosome	IDA IDA: Inferred from direct assay	2169885	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
L-dopachrome tautomerase	DOPAchrome conversion factor DOPAchrome isomerase DOPAchrome oxidoreductase L-dopachrome Delta-isomerase SLATY locus protein tyrosinase-related protein 2

Recombinant Dct Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P72169	DCT Protein, Mouse (His-SUMO)	P29812 (Q24-S472)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-113042	Prostaglandin B2		≥99.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (11)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-D0168	Orcinol		99.97%	Unkown
HY-138561C	EFdA-TP tetralithium	Inhibitor	96.91%	Unkown
HY-N2983	Cajanin	Inhibitor	99.96%	Unkown
HY-138561A	EFdA-TP tetraammonium	Inhibitor	98.03%	Unkown
HY-138561B	EFdA-TP tetrasodium	Inhibitor	95.18%	Unkown
HY-138561	EFdA-TP	Inhibitor	/	Unkown
HY-148412	Monarsen	Inhibitor	/	Unkown
HY-RS03591	DCT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174722	Human DCT mRNA		/	Unkown
HY-RS17790	Dct Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24258	Dct Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dct	NCBI	NCBI:1638