Dnmt3a - DNA methyltransferase 3A Gene

Also Known as MmuIIIA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13435

Summary

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]

Dnmt3a Products (3)

mRNA Protein Name
NM_001271753.1 NP_001258682.1 DNA (cytosine-5)-methyltransferase 3A isoform 1
NM_007872.4 NP_031898.1 DNA (cytosine-5)-methyltransferase 3A isoform 1
NM_153743.4 NP_714965.1 DNA (cytosine-5)-methyltransferase 3A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA (cytosine-5-)-methyltransferase activity IDA
IDA: Inferred from direct assay
9662389 MGI
enables DNA (cytosine-5-)-methyltransferase activity IGI
IGI: Inferred from genetic interaction
17938196 MGI
enables DNA binding IDA
IDA: Inferred from direct assay
11399089 MGI
enables lncRNA binding IDA
IDA: Inferred from direct assay
25686699 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11934864 MGI
enables protein-cysteine methyltransferase activity IDA
IDA: Inferred from direct assay
21481189 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA methylation-dependent heterochromatin formation IGI
IGI: Inferred from genetic interaction
17938196 MGI
involved in autosome genomic imprinting IDA
IDA: Inferred from direct assay
21047779 MGI
acts upstream of or within autosome genomic imprinting IMP
IMP: Inferred from mutant phenotype
11934864 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within cellular response to bisphenol A IDA
IDA: Inferred from direct assay
21980460 MGI
acts upstream of or within epigenetic programming of gene expression IGI
IGI: Inferred from genetic interaction
10555141 MGI
acts upstream of or within epigenetic programming of gene expression IMP
IMP: Inferred from mutant phenotype
20385583 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
15215868 MGI
involved in genomic imprinting IMP
IMP: Inferred from mutant phenotype
15215868 MGI
acts upstream of or within heterochromatin formation IMP
IMP: Inferred from mutant phenotype
22516971 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IDA
IDA: Inferred from direct assay
30834655 MGI
involved in negative regulation of gene expression via chromosomal CpG island methylation IDA
IDA: Inferred from direct assay
21047779 MGI
acts upstream of or within post-embryonic development IDA
IDA: Inferred from direct assay
30834655 MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation IPI
IPI: Inferred from physical interaction
32674113 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11934864 MGI
Cellular Component GO Annotation Evidence References Source
located in XY body IDA
IDA: Inferred from direct assay
20577743 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
15456878 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15739230 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
11934864 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14752048 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA (cytosine-5)-methyltransferase 3A

  • DNA MTase MmuIIIA

  • DNA methyltransferase MmuIIIA

  • cysteine methyltransferase DNMT3A

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2194 γ-Oryzanol Inhibitor 99.66% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-176230 DNMT-IN-5 Inhibitor / Phase 3

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13962 SGI-1027 99.79% Unkown
HY-151136 DY-46-2 Inhibitor 99.86% Unkown
HY-101925 CM-272 98.0% Unkown
HY-144433 DNMT3A-IN-1 Inhibitor 99.94% Unkown
HY-124131 DS-437 Inhibitor 99.22% Unkown
HY-RS03911 DNMT3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-111544 EML741 Inhibitor / Unkown
HY-179409 MC3817 / Unkown
HY-13689G Go 6983 (GMP) / Unkown
HY-150025 (4aS,8aR)-NPD-001 / Unkown
HY-172217 DNMT1-IN-5 / Unkown
HY-179409A MC3817 free base / Unkown
HY-181690 Menin-MLL-IN-37 Inhibitor / Unkown
HY-181955 MS1129 / Unkown
HY-182009 DNMT-IN-6 / Unkown
HY-182956 DNMT1 Degrader-1 Degrader / Unkown
HY-184332 DNMT3A-IN-4 Inhibitor / Unkown
HY-RS16763 Dnmt3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23203 Dnmt3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnmt3a NCBI NCBI:1788