Eda - ectodysplasin-A Gene

Also Known as Ta; Ed1; HED; EDA1; XLHED; tabby; Eda-A1; Eda-A2; Tnlg7c

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13607

Summary

Predicted to enable death receptor agonist activity and death receptor binding activity. Acts upstream of or within several processes, including animal organ development; cell-matrix adhesion; and positive regulation of signal transduction. Located in apical part of cell and endoplasmic reticulum membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; future brain; nasal gland epithelium; and skin. Used to study hypohidrotic ectodermal dysplasia. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A). [provided by Alliance of Genome Resources, Apr 2022]

Eda Products (9)

mRNA Protein Name
NM_001177937.1 NP_001171408.1 ectodysplasin-A isoform 2
NM_001177938.1 NP_001171409.1 ectodysplasin-A isoform 3
NM_001177939.1 NP_001171410.1 ectodysplasin-A isoform 4
NM_001177940.1 NP_001171411.1 ectodysplasin-A isoform 5
NM_001177941.1 NP_001171412.1 ectodysplasin-A isoform 6
NM_001177942.1 NP_001171413.1 ectodysplasin-A isoform 7
NM_001177943.1 NP_001171414.1 ectodysplasin-A isoform 8
NM_001177944.1 NP_001171415.1 ectodysplasin-A isoform 8
NM_010099.2 NP_034229.1 ectodysplasin-A isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19619491 MGI
acts upstream of or within cell-matrix adhesion IDA
IDA: Inferred from direct assay
10534613 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
17673451 MGI
acts upstream of or within hair follicle development IGI
IGI: Inferred from genetic interaction
18689798 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
544312 MGI
acts upstream of or within hair follicle placode formation IGI
IGI: Inferred from genetic interaction
19619491 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
5893447 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
4561716 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
18689798 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19619491 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
18508042 MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
12629675 MGI
acts upstream of or within salivary gland cavitation IDA
IDA: Inferred from direct assay
12629675 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
17673451 MGI
acts upstream of or within trachea gland development IMP
IMP: Inferred from mutant phenotype
15973734 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12629675 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10534613 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10534613 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ectodysplasin-A

  • EDA protein homolog

  • tumor necrosis factor ligand 7c

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2587 Irigenin 99.84% Unkown
HY-130893 Biotin-EDA 99.76% Unkown
HY-126688 Mal-C2-Gly3-EDA-PNU-159682 93.43% Unkown
HY-D1603 BODIPY FL-EDA 97.86% Unkown
HY-147097A EDA-DA TFA 95.0% Unkown
HY-114346A BODIPY FL EDA free base / Unkown
HY-125810 4'-Ethynyl-2'-deoxyadenosine Inhibitor / Unkown
HY-126673 Mal-C2-Gly3-EDA / Unkown
HY-130893A Biotin-EDA TFA / Unkown
HY-130893B Biotin-EDA hydrobromide / Unkown
HY-145078 PNU-EDA-Gly5 / Unkown
HY-147097 EDA-DA / Unkown
HY-171489 Mal-VC-PAB-EDA-N-Ac-Calicheamicin / Unkown
HY-D1395 RH-EDA / Unkown
HY-P11849 NOTA-PTP / Unkown
HY-RS04151 EDA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04152 EDA2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151829 Fmoc-L-Asn(EDA-N3)-OH / Unkown
HY-151842 Fmoc-EDA-N3 / Unkown
HY-186077 PEDA / Unkown
HY-RS16949 Eda Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18272 Eda2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23392 Eda Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24750 Eda2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eda NCBI NCBI:1896
Macaca fascicularis Eda NCBI NCBI:102126767
Rattus norvegicus Eda NCBI NCBI:302424