Gls - glutaminase Gene

Also Known as 6330442B14; B230365M23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14660

About Gls

Chromosome 1: 52,202,607-52,272,391 reverse strand.GRCm39:CM000994.3

This gene has 17 transcripts (splice variants), 305 orthologues, 1 paralogue and is associated with 7 phenotypes. Broad expression in CNS E18 (RPKM 2.), cortex adult (RPKM 19.9) and 26 other tissues.

Summary

Enables Glutaminase activity and identical protein binding activity. Involved in glutamate biosynthetic process; glutamine catabolic process; and protein homotetramerization. Acts upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (Glutaminase). [provided by Alliance of Genome Resources, Apr 2022]

Gls Products (2)

mRNA Protein Name
NM_001113383.1 NP_001106854.1 glutaminase kidney isoform, mitochondrial isoform 2
NM_001081081.2 NP_001074550.1 glutaminase kidney isoform, mitochondrial isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables glutaminase activity IDA
IDA: Inferred from direct assay
22228304 MGI
enables glutaminase activity IMP
IMP: Inferred from mutant phenotype
16641247 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
22228304 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16899818 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
16641247 MGI
involved in glutamate biosynthetic process IDA
IDA: Inferred from direct assay
22228304 MGI
involved in glutamine catabolic process IDA
IDA: Inferred from direct assay
22228304 MGI
acts upstream of or within glutamine catabolic process IMP
IMP: Inferred from mutant phenotype
16641247 MGI
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
22228304 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IMP
IMP: Inferred from mutant phenotype
16641247 MGI
acts upstream of or within suckling behavior IMP
IMP: Inferred from mutant phenotype
16641247 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gls Protein Structure

EF-hand_14

EF-hand_14: pfam17959 (143 - 226)

Glutaminase

Glutaminase: pfam04960 (248 - 532)

ANK

ANK: sd00045 (561 - 587)

Ank_2

Ank_2: pfam12796 (561 - 653)

ANK

ANK: sd00045 (589 - 621)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
Protein Preferred Names Protein Names

glutaminase kidney isoform, mitochondrial

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-12248 Telaglenastat 99.82% Phase 2
HY-128357 Ibezapolstat Inhibitor 98.0% Phase 2
HY-P2760 Glutaminase Control / Phase 2
HY-108917A Morphothiadin mesylate Inhibitor / Phase 2
HY-103671 IPN60090 Inhibitor 98.96% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99109 Zimberelimab Inhibitor 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108917 Morphothiadin Inhibitor 99.79% Unkown
HY-150109A Purinostat Inhibitor 98.04% Unkown
HY-136704 GLS1 Inhibitor-1 Inhibitor 98.59% Unkown
HY-79583 Glutaminase-IN-3 Inhibitor 99.88% Unkown
HY-12248A Telaglenastat hydrochloride 98.03% Unkown
HY-103671A IPN60090 dihydrochloride Inhibitor 99.68% Unkown
HY-144666 GLS-1-IN-1 Inhibitor 99.83% Unkown
HY-RS05500 GLS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151434 GLS1 Inhibitor-6 / Unkown
HY-146616 GLS1 Inhibitor-3 Inhibitor / Unkown
HY-146617 GLS1 Inhibitor-4 / Unkown
HY-146658 Glutaminase-IN-4 Inhibitor / Unkown
HY-148241 A-446 Inhibitor / Unkown
HY-152207 LWG-301 / Unkown
HY-155138 GLS1 Inhibitor-7 Inhibitor / Unkown
HY-174211 JNK-IN-23 Inhibitor / Unkown
HY-179003 mTOR/GLS1-IN-1 / Unkown
HY-181890 TRG-192 Inhibitor / Unkown
HY-RS05501 Gls Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05502 Gls Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05503 GLS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128357A Ibezapolstat hydrochloride Inhibitor / Unkown
HY-RS17808 Gls2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24276 Gls2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990976 Brivestobart 99.198% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gls NCBI NCBI:2744