CYP2B6 - cytochrome P450 family 2 subfamily B member 6 Gene

Also Known as CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1555

About CYP2B6

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,991,282-41,018,398 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues, 15 paralogues and is associated with 1 phenotype. Restricted expression toward liver (RPKM 124.8).

Summary

This gene, CYP2B6, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of Cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

CYP2B6 Products (2)

mRNA	Protein	Name
NM_000767.5	NP_000758.1	cytochrome P450 2B6 precursor
NM_000767.5	NP_000758.1	cytochrome P450 2B6 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables anandamide 11,12 epoxidase activity	IDA IDA: Inferred from direct assay	21289075	GOA
enables anandamide 14,15 epoxidase activity	IDA IDA: Inferred from direct assay	21289075	GOA
enables anandamide 8,9 epoxidase activity	IDA IDA: Inferred from direct assay	21289075	GOA
enables estrogen 2-hydroxylase activity	IDA IDA: Inferred from direct assay	12865317	GOA
enables heme binding	IDA IDA: Inferred from direct assay	20061448	GOA
enables monooxygenase activity	IDA IDA: Inferred from direct assay	19651758	GOA
enables testosterone 16-alpha-hydroxylase activity	IDA IDA: Inferred from direct assay	21289075	GOA
enables testosterone 16-beta-hydroxylase activity	IDA IDA: Inferred from direct assay	21289075	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular ketone metabolic process	IDA IDA: Inferred from direct assay	19651758	GOA
involved in steroid metabolic process	IMP IMP: Inferred from mutant phenotype	18356043	GOA
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	19029318	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	19651758	GOA
involved in xenobiotic metabolic process	IMP IMP: Inferred from mutant phenotype	18356043	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP2B6 Protein Structure

p450

0
100
200
300
400
491 a.a.

Protein Preferred Names	Protein Names
cytochrome P450 2B6	1,4-cineole 2-exo-monooxygenase

Related Diseases

Diseases	Alias
Efavirenz, Poor Metabolism Of	Efavirenz Central Nervous System Toxicity, Susceptibility To Efavirenz Central Nervous System Toxicity
Congenital Nystagmus 4	Nys4 Vestibulocerebellar Disorder With Predominant Ocular Signs Nystagmus 4, Congenital, Autosomal Dominant Autosomal Dominant Congenital Nystagmus 4
Acute Frontal Sinusitis
Neonatal Abstinence Syndrome	Drug Withdrawal Syndrome In Newborn
Nystagmus 5, Congenital, X-Linked	NYS5 Congenital Nystagmus 5 X-Linked Congenital Nystagmus 5 Nystagmus 5, Infantile Periodic Alternating
Abacavir Allergy	Abc Allergy
Vitreous Abscess
Hypertrophy Of Tongue Papillae	Tongue Papillary Hypertrophy Hypertrophy Of Foliate Papillae
Nystagmus 3, Congenital, Autosomal Dominant	NYS3 Congenital Nystagmus 3 Autosomal Dominant Congenital Nystagmus 3
Hemorrhagic Cystitis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Drug-Induced Stevens Johnson Syndrome Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Susceptibility To Severe Cutaneous Adverse Reaction Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Lyell'S Syndrome Lyell Syndrome Severe Cutaneous Adverse Reaction, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced Stevens-Johnson Syndrome, Susceptibility To Toxic Epidermal Necrolysis, Susceptibility To Sjs/Ten Susceptibility To Severe Cutaneous Adverse Reaction Ity To Mycoplasma-Induced Stevens Johnson Syndrome Dermatostomatitis, Stevens Johnson Type Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum Sjs-Ten Toxic Epidermolysis SJS Dermatostomatitis Stevens Johnson Type Ten Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis] Ten - [Toxic Epidermal Necrolysis]
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Liver Benign Neoplasm	Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Retinitis Pigmentosa 44	RP44 Retinitis Pigmentosa, Type 44
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Familial Nonhemolytic Jaundice Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17356	Fenofibrate		99.97%	Yes
HY-17459	Clopidogrel hydrogen sulfate	Inhibitor	99.88%	Yes
HY-B1184	Mephenytoin		99.96%	Unkown
HY-17459R	Clopidogrel hydrogen sulfate (Standard)	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136610	Chlorpyrifos-oxon	Inhibitor	99.39%	Unkown
HY-100637	Hydroxybupropion		99.91%	Unkown
HY-N0762	Isobavachin		99.88%	Unkown
HY-154980	NXE0041178	Agonist	99.97%	Unkown
HY-W040468	2-Phenyl-2-(1-piperidinyl)propane	Inhibitor	99.72%	Unkown
HY-N1050	Zederone	Inhibitor	99.61%	Unkown
HY-17356R	Fenofibrate (Standard)		99.92%	Unkown
HY-W010195	2,6-Dimethylquinoline	Inhibitor	99.95%	Unkown
HY-W587878	Thujopsene		86.31%	Unkown
HY-17356S	Fenofibrate-d6		99.70%	Unkown
HY-N5132	(-)-Fenchone		98.0%	Unkown
HY-N6065	Praeruptorin A		99.57%	Unkown
HY-W754151	N-Desmethyl apalutamide-d4		99.63%	Unkown
HY-B0365AS	Memantine-d6 hydrochloride		99.83%	Unkown
HY-B1184S1	Mephenytoin-d5		98.72%	Unkown
HY-W067374	Aripiprazole impurity 38		97.79%	Unkown
HY-10572A	(R)-Efavirenz	Inhibitor	/	Unkown
HY-110134	S07662	Inhibitor	/	Unkown
HY-112142A	(Rac)-AB-423	Inhibitor	/	Unkown
HY-117593	NSC 23925B	Inhibitor	/	Unkown
HY-134522	DL5050	Agonist	/	Unkown
HY-173465	DL5055	Agonist	/	Unkown
HY-17356G	Fenofibrate (GMP)		/	Unkown
HY-17356S1	Fenofibrate-d4		/	Unkown
HY-17459S	Clopidogrel-d3 hydrogen sulfate		/	Unkown
HY-182582	ZY12201		/	Unkown
HY-183763	RORγt inverse agonist 37		/	Unkown
HY-B1184S2	Mephenytoin-d8		/	Unkown
HY-B1184S3	Mephenytoin-13C,d3		/	Unkown
HY-N11706	β-Cedrene	Inhibitor	98.94%	Unkown
HY-RS03456	CYP2B6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W099758	Gamma-heptalactone	Inhibitor	99.90%	Unkown
HY-W140208	3-Phenylthiophene	Inhibitor	/	Unkown
HY-17356S2	Fenofibrate-13C6		/	Unkown
HY-B1184S	Mephenytoin-d3		99.52%	Unkown
HY-W587570	(S)-4-Hydroxymephenytoin		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CYP2B6	VGNC	VGNC:110240
Rattus norvegicus	CYP2B6	RGD	RGD:628627
Macaca mulatta	CYP2B6	VGNC	VGNC:103599
Others	CYP2B6	NCBI