2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. 3-Phenylthiophene

3-Phenylthiophene (Compound 25) is a CYP2A6 inhibitor with a Ki value of 3.3 μM. The Ki values for CYP2E1, CYP2B6, CYP2C9, and CYP2C19 are 9.7, 14, 112, and 107 μM respectively. It shows no significant inhibition on CYP3A4 and CYP2D6. 3-Phenylthiophene can be used in smoking cessation research.

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3-Phenylthiophene

3-Phenylthiophene Chemical Structure

CAS No. : 2404-87-7

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Based on 1 publication(s) in Google Scholar

3-Phenylthiophene Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

3-Phenylthiophene (Compound 25) is a CYP2A6 inhibitor with a Ki value of 3.3 μM. The Ki values for CYP2E1, CYP2B6, CYP2C9, and CYP2C19 are 9.7, 14, 112, and 107 μM respectively. It shows no significant inhibition on CYP3A4 and CYP2D6. 3-Phenylthiophene can be used in smoking cessation research[1].

IC50 & Target[1]

CYP2A6

3.3 μM (Ki)

CYP2E1

9.7 μM (Ki)

CYP2B6

14 μM (Ki)

CYP2C9

112 μM (Ki)

CYP2C19

107 μM (Ki)

CYP3A4

> 400 μM (Ki)

CYP2D6

> 400 μM (Ki)

Molecular Weight

160.23

Formula

C10H8S
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

S1C=CC(=C1)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
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3-Phenylthiophene Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Phenylthiophene2404-87-7Cytochrome P450CYPsenzyme inhibitorstructure-activity relationshipkineticsselectivitymechanism-based inactivationcocrystallizationnicotine analoguesInhibitorinhibitorinhibit

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