CYP2C9 - cytochrome P450 family 2 subfamily C member 9 Gene

Homo sapiens

Also known as CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9; P450IIC9

Gene ID: 1559 | Gene type: protein coding

About CYP2C9

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:94,938,658-94,990,091 (from NCBI)

This gene has 5 transcripts (splice variants), 43 orthologues, 15 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 331.8), duodenum (RPKM 60.3) and 1 other tissue.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The Enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of Cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

CYP2C9 Products(1)

mRNA	Protein	Name
NM_000771.4	NP_000762.2	cytochrome P450 2C9 precursor

CYP2C9 Protein Structure

p450

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 2C9

cytochrome P-450 S-mephenytoin 4-hydroxylase

Related Diseases

Diseases

Alias

Coumarin Resistance

Warfarin Resistance	Warfarin Sensitivity
Coumadin Sensitivity	Warfarin Response
Poor Metabolism Of Coumarin	Coumarin, Poor Metabolism Of
CMRES

Multiple Chemical Sensitivity

Environmental Illness	20th Century Disease
Chemical Aids	Idiopathic Environmental Illness
Total Allergy Syndrome

Budd-Chiari Syndrome

Hepatic Vein Thrombosis	Chiari Syndrome
BDCHS	Membranous Obstruction Of The Inferior Vena Cava
Budd-Chiari Syndrome, Somatic	Movc
Budd-Chiari Syndrome, Susceptibility To, Somatic	Budd-Chiari Syndrome, Susceptibility To
Membranous Obstruction Of Inferior Vena Cava	Hepatic Vein Block
Obstruction Of Hepatic Veins	Hepatic Vein Obstruction
Hepatic Venous Block

Halothane Hepatitis

Hepatitis Halothane

Sulfamethoxazole Allergy

Smx Allergy	Smz Allergy
Sulphamethoxazole Allergy

Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2

VKCFD2	Combined Deficiency Of Vitamin K-Dependent Clotting Factors 2
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 2

Impotence

Erectile Dysfunction	Sexual Impotence
Erectile Dysfunction Adverse Event

Severe Cutaneous Adverse Reaction

Stevens-Johnson Syndrome	Toxic Epidermal Necrolysis
Drug-Induced Stevens Johnson Syndrome	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Susceptibility To Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Lyell'S Syndrome	Lyell Syndrome
Severe Cutaneous Adverse Reaction, Susceptibility To	Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To
Hypersensitivity Syndrome, Carbamazepine-Induced	Stevens-Johnson Syndrome, Susceptibility To
Toxic Epidermal Necrolysis, Susceptibility To	Sjs/Ten
Susceptibility To Severe Cutaneous Adverse Reaction Ity To	Mycoplasma-Induced Stevens Johnson Syndrome
Dermatostomatitis, Stevens Johnson Type	Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Sjs-Ten	Toxic Epidermolysis
SJS	Dermatostomatitis Stevens Johnson Type
Ten	Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis]
Ten - [Toxic Epidermal Necrolysis]

Angiodysplasia Of Intestine

Drug-Induced Hepatitis

Drug-Induced Chronic Hepatitis	Chemical And Drug Induced Liver Injury, Chronic
Hepatitis, Drug-Induced	Hepatitis, Chronic, Drug-Induced

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Marfan Syndrome

MFS	Mfs1
Marfan'S Syndrome	Marfan Syndrome Type 1
Marfan Syndrome, Type I	Mass Phenotype
Contractural Arachnodactyly	Mass Syndrome
Octd	Overlap Connective Tissue Disease
Marfanoid Hypermobility Syndrome	Marfan Disease

Trimethoprim Allergy

Primsol Allergy	Proloprim Allergy
Tmp Allergy

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Hypertrophy Of Tongue Papillae

Tongue Papillary Hypertrophy

Hypertrophy Of Foliate Papillae

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Invasive Aspergillosis

Aspergillosis Invasive

Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy

Abacavir Allergy

Abc Allergy

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Phenytoin Allergy

Dilantin Allergy

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Heart Conduction Disease

Conduction Disorder Of The Heart

Heart Rhythm Disease

Lennox-Gastaut Syndrome

Lennox Syndrome	Encephalopathy Of Childhood
Epileptic Encephalopathy Lennox-Gastaut Type	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Gilbert Syndrome

Gilbert Disease	Gilbert'S Disease
Gilbert'S Syndrome	Cholemia, Familial
Familial Nonhemolytic Jaundice	Meulengracht Syndrome
Gilbert Syndrome, Susceptibility To	Hyperbilirubinemia, Gilbert Type
Hblrg	Hyperbilirubinemia, Arias Type
Hyperbilirubinemia I	Constitutional Hyperbilirubinemia
Gilbert-Meulengracht Syndrome	Hereditary Nonhemolytic Jaundice
Hyperbilirubinemia Arias Type	Hyperbilirubinemia Type 1
Constitutional Liver Dysfunction	Gilbert-Lereboullet Syndrome
Hyperbilirubinemia 1	Unconjugated Benign Bilirubinemia
GILBS	Gilberts Syndrome
Familial Nonhaemolytic Jaundice	Constitutional Hyperbilirubinaemia
Hereditary Nonhaemolytic Bilirubinaemia	Familial Nonhaemolytic Bilirubinaemia
Idiopathic Hyperbilirubinaemia	Icterus Intermittens Juvenilis
Chronic Intermittent Juvenile Jaundice	Low-Grade Chronic Hyperbilirubinaemia Syndrome
Benign Unconjugated Bilirubinaemia Syndrome	Hereditary Nonhaemolytic Jaundice
Idiopathic Unconjugated Hyperbilirubinaemia	Gilbert--Lereboullet Syndrome
Constitutional Hepatic Dysfunction	Meulengracht Icterus
Cholaemia Familiaris Simplex	Familial Cholaemia
Congenital Familial Cholaemia	Physiologic Cholaemia
Hyperbilirubinaemia Type 1	Gilbert Cholaemia

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diabetes Mellitus

Diabetes

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17356	Fenofibrate		99.93%	Yes
HY-N6972	Cepharanthine		99.91%	Yes
HY-B1218	Sulfaphenazole	Inhibitor	99.83%	Unkown
HY-B0258	Gemfibrozil		99.91%	Yes
HY-B0281A	Ranitidine hydrochloride		99.88%	Yes
HY-13463	Avatrombopag	Agonist	99.83%	Yes
HY-100386	Ticlopidine		99.34%	Unkown
HY-13463B	Avatrombopag hydrochloride	Agonist	98.53%	Yes
HY-13463A	Avatrombopag maleate	Agonist	/	Unkown
HY-B0693	Ranitidine		/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N1201	Apigenin		99.58%	Phase 2
HY-114415	AWZ1066S	Inhibitor	98.64%	Phase 1
HY-12946	BI 653048		/	Phase 1
HY-12946A	BI 653048 phosphate	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (48)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0043	Ginsenoside Rd	Inhibitor	98.07%	Unkown
HY-N0904	Ginsenoside C-K	Inhibitor	≥98.0%	Unkown
HY-N0893	Tetrahydrocurcumin		99.43%	Unkown
HY-15565	APD668		99.10%	Unkown
HY-15550S	4'-Hydroxy diclofenac-d4		98.92%	Unkown
HY-14362	GSK-25	Inhibitor	99.68%	Unkown
HY-15550	4'-Hydroxy diclofenac		99.62%	Unkown
HY-N2071	Cedrol	Inhibitor	≥98.0%	Unkown
HY-148822	Nampt activator-2	Activator	98.80%	Unkown
HY-114759	MS-PPOH	Inhibitor	99.27%	Unkown
HY-N0688	Linderane	Inhibitor	99.61%	Unkown
HY-100641S	4-Hydroxytolbutamide-d9		≥99.0%	Unkown
HY-17356R	Fenofibrate (Standard)		99.91%	Unkown
HY-B0258S	Gemfibrozil-d6		98.00%	Unkown
HY-B0258R	Gemfibrozil (Standard)		99.90%	Unkown
HY-N8382	Chalepensin	Inhibitor	≥98.0%	Unkown
HY-128859	EMT inhibitor-2	Inhibitor	99.55%	Unkown
HY-131910	IHMT-PI3Kδ-372	Inhibitor	99.75%	Unkown
HY-135390	Hydroxy desmethyl Bosentan		/	Unkown
HY-100386S	Ticlopidine-d4	Inhibitor	/	Unkown
HY-116862	Dibenzylfluorescein		/	Unkown
HY-119996	AR-C141990		/	Unkown
HY-13463BS	Avatrombopag-d8 hydrochloride	Agonist	/	Unkown
HY-141547	Nav1.7-IN-8	Inhibitor	/	Unkown
HY-143906	URAT1 inhibitor 2	Inhibitor	/	Unkown
HY-144652	IDO1-IN-19	Inhibitor	98.52%	Unkown
HY-147807	HIV-1 inhibitor-40	Inhibitor	/	Unkown
HY-148597	FGFR-IN-10	Inhibitor	/	Unkown
HY-149866	HIV-1 inhibitor-58	Inhibitor	/	Unkown
HY-151251	CYP2C9/CYP2C19-IN-1	Inhibitor	/	Unkown
HY-151253	CYP2C1/CYP2C19-IN-2	Inhibitor	/	Unkown
HY-153970	URAT1 inhibitor 7	Inhibitor	/	Unkown
HY-15550S1	4'-Hydroxy diclofenac-13C6		/	Unkown
HY-161350	ALK/HDAC-IN-1	Inhibitor	/	Unkown
HY-17356G	Fenofibrate (GMP)		/	Unkown
HY-17356S	Fenofibrate-d6		/	Unkown
HY-17356S1	Fenofibrate-d4		/	Unkown
HY-18063	ML252	Inhibitor	/	Unkown
HY-B0281AS	Ranitidine-d6 hydrochloride		/	Unkown
HY-N0043R	Ginsenoside Rd (Standard)	Inhibitor	/	Unkown
HY-N0893S	Tetrahydrocurcumin-d6		/	Unkown
HY-N0904R	Ginsenoside C-K (Standard)	Inhibitor	/	Unkown
HY-N1201R	Apigenin (Standard)		/	Unkown
HY-N6023	Thermopsoside	Inhibitor	/	Unkown
HY-RS03460	CYP2C9 Human Pre-designed siRNA Set A		/	Unkown
HY-U00048	Bucolome	Inhibitor	98.93%	Unkown
HY-116601	6-Hydroxywarfarin		/	Unkown
HY-100641	4-Hydroxytolbutamide		/	Unkown

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