Il17ra - interleukin 17 receptor A Gene

Also Known as Il17r; Cdw217; VDw217

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16172

Summary

Enables interleukin-17 receptor activity and signaling receptor binding activity. Involved in several processes, including granulocyte chemotaxis; interleukin-17-mediated signaling pathway; and positive regulation of cytokine production involved in inflammatory response. Acts upstream of or within positive regulation of interleukin-13 production and positive regulation of interleukin-5 production. Located in plasma membrane. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 51. Orthologous to human IL17RA (interleukin 17 receptor A). [provided by Alliance of Genome Resources, Apr 2022]

Il17ra Products (1)

mRNA	Protein	Name
NM_008359.2	NP_032385.1	interleukin-17 receptor A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-17 receptor activity	IDA IDA: Inferred from direct assay	33723527	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19825828	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	20554964	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 17 type immune response	IDA IDA: Inferred from direct assay	28561022	MGI
involved in defense response to fungus	IMP IMP: Inferred from mutant phenotype	20554964	MGI
involved in granulocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	20554964	MGI
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	19825828	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	33723527	MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response	IGI IGI: Inferred from genetic interaction	16785495	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	33723527	MGI
acts upstream of or within positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18768888	MGI
acts upstream of or within positive regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	18768888	MGI
acts upstream of or within positive regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	18768888	MGI
involved in protein catabolic process	IDA IDA: Inferred from direct assay	28561022	MGI
involved in response to virus	IDA IDA: Inferred from direct assay	33723527	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17911633	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-17 receptor A	IL-17 receptor A IL-17RA

Recombinant Il17ra Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72583	IL-17RA Protein, Mouse (HEK293, Fc)	Q60943 (S32-W322)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74827	IL-17RA Protein, Mouse (HEK293, His)	Q60943/NP_032385.1 (S32-W322)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9924	Ixekizumab	Inhibitor	99.00%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991266	SM-17	Inhibitor	96.98%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18197	Il17ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-178714	JNJ627	Inhibitor	/	Unkown
HY-RS06702	IL17RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174632	Human IL17RA mRNA		/	Unkown
HY-RS24671	Il17ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il17ra	NCBI	NCBI:23765