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Ajuba - ajuba LIM protein Gene

Also Known as Jub

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16475

Summary

Enables several functions, including actin filament binding activity; alpha-catenin binding activity; and transcription corepressor activity. Acts upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of intracellular signal transduction; and regulation of cellular biosynthetic process. Located in several cellular components, including cytosol; focal adhesion; and lamellipodium. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and tooth. Orthologous to human AJUBA (ajuba LIM protein). [provided by Alliance of Genome Resources, Apr 2022]

Ajuba Products (1)

mRNA	Protein	Name
NM_010590.5	NP_034720.2	LIM domain-containing protein ajuba

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	12417594	MGI
enables alpha-catenin binding	IDA IDA: Inferred from direct assay	12417594	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18347060	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10330178	MGI
enables protein kinase activator activity	IMP IMP: Inferred from mutant phenotype	15870274	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	17909014	MGI
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	18331720	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	12417594	MGI
acts upstream of or within focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	15728191	MGI
acts upstream of or within glycerophospholipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15870270	MGI
acts upstream of or within lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	15728191	MGI
acts upstream of or within negative regulation of kinase activity	IDA IDA: Inferred from direct assay	15870270	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18347060	MGI
acts upstream of or within positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	10330178	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15870274	MGI
acts upstream of or within positive regulation of cellular biosynthetic process	IMP IMP: Inferred from mutant phenotype	15870270	MGI
acts upstream of or within positive regulation of kinase activity	IDA IDA: Inferred from direct assay	15870270	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	15870270	MGI
acts upstream of or within regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	15728191	MGI
acts upstream of or within regulation of cell migration	IDA IDA: Inferred from direct assay	15728191	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15728191	MGI
acts upstream of or within wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	15728191	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	10330178	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	15728191	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	15728191	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18331720	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	18347060	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
LIM domain-containing protein ajuba	protein ajuba

Ajuba Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Ajuba	Q91XC0	PRMT5	Homo sapiens	O14744	Anti Tag CoIP	20133701
Cross	Ajuba	Q91XC0	PRMT5	Homo sapiens	O14744	Pull Down	20133701
Cross	Ajuba	Q91XC0	RARA	Homo sapiens	P10276	Pull Down	20133701
Cross	Ajuba	Q91XC0	RARA	Homo sapiens	P10276	Anti Tag CoIP	20133701
Cross	Ajuba	Q91XC0	RARA	Homo sapiens	P10276	GMS	20133701
Cross	Ajuba	Q91XC0	RXRG	Homo sapiens	P48443	Anti Tag CoIP	20133701
Intra	Ajuba	Q91XC0	Rarg	Mus musculus	P18911	Anti Tag CoIP	20133701

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00504	AJUBA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ajuba	NCBI	NCBI:84962