Nos1 - nitric oxide synthase 1, neuronal Gene

Also Known as NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18125

About Nos1

Chromosome 5: 117,919,097-118,096,905 forward strand.GRCm39:CM000998.3

This gene has 7 transcripts (splice variants), 198 orthologues, 5 paralogues and is associated with 113 phenotypes. Biased expression in cerebellum adult (RPKM 7.6), frontal lobe adult (RPKM 4.) and 12 other tissues.

Summary

Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating Adrenergic Receptor signaling pathway involved in heart process; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nos1 Products (1)

mRNA Protein Name
NM_008712.3 NP_032738.1 nitric oxide synthase, brain

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nitric-oxide synthase activity IDA
IDA: Inferred from direct assay
7545544 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7545544 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of calcium ion transport IMP
IMP: Inferred from mutant phenotype
12074580 MGI
involved in cellular response to growth factor stimulus IMP
IMP: Inferred from mutant phenotype
16427017 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12074580 MGI
acts upstream of or within negative regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
12074580 MGI
acts upstream of or within negative regulation of hydrolase activity IMP
IMP: Inferred from mutant phenotype
12074580 MGI
acts upstream of or within negative regulation of potassium ion transport IMP
IMP: Inferred from mutant phenotype
12074580 MGI
involved in negative regulation of serotonin uptake IDA
IDA: Inferred from direct assay
17452640 MGI
involved in nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
7545544 MGI
acts upstream of or within peptidyl-cysteine S-nitrosylation IDA
IDA: Inferred from direct assay
17293453 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16427017 MGI
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17242280 MGI
involved in positive regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
17242280 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12834919 MGI
acts upstream of potassium ion transport IMP
IMP: Inferred from mutant phenotype
12074580 MGI
involved in regulation of neurogenesis IDA
IDA: Inferred from direct assay
21960957 MGI
involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
19038221 MGI
involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
19038221 MGI
acts upstream of or within regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
12074580 MGI
acts upstream of or within striated muscle contraction IMP
IMP: Inferred from mutant phenotype
16537391 MGI
involved in synaptic signaling by nitric oxide IDA
IDA: Inferred from direct assay
19038221 MGI
involved in synaptic signaling by nitric oxide IMP
IMP: Inferred from mutant phenotype
19038221 MGI
acts upstream of or within xenobiotic catabolic process IMP
IMP: Inferred from mutant phenotype
11158245 MGI
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
19800018 MGI
located in Z disc IDA
IDA: Inferred from direct assay
19800018 MGI
is active in calyx of Held IDA
IDA: Inferred from direct assay
19038221 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
19038221 MGI
colocalizes with caveola IDA
IDA: Inferred from direct assay
19800018 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
7545544 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
10037495 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
19800018 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
7545544 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
19800018 MGI
located in synapse IDA
IDA: Inferred from direct assay
10995443 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nos1 Protein Structure

PDZ_signaling

PDZ_signaling: cd00992 (14 - 97)

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (299 - 710)

Flavodoxin_1

Flavodoxin_1: pfam00258 (756 - 929)

Nitric_oxide_synthase

Nitric_oxide_synthase: cd06202 (995 - 1398)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1429 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, brain

  • NOS type I

  • constitutive NOS

  • neuronal NOS

  • neuronal nitric oxide synthase

  • peptidyl-cysteine S-nitrosylase NOS1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18732 L-NMMA Inhibitor 99.43% Phase 4

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6607 Tryptanthrin 99.89% Unkown
HY-130452 NOS1-IN-1 Inhibitor 95.0% Unkown
HY-107720 ARL 17477 Inhibitor 99.02% Unkown
HY-RS09433 NOS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12117 L-NIL hydrochloride Inhibitor / Unkown
HY-124996 (Rac)-ZLc-002 Inhibitor 98.11% Unkown
HY-101304 S-Isopropylisothiourea hydrobromide Inhibitor 98.0% Unkown
HY-RS09021 NANOS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09434 Nos1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09435 Nos1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09436 NOS1AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19265 Nos1ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21891 Nanos1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25754 Nos1ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nos1 NCBI NCBI:4842