Eif4a3 - eukaryotic translation initiation factor 4A3 Gene

Also Known as Ddx48; eIF4A-III; mKIAA0111; 2400003O03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 192170

Summary

Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in submandibular gland primordium; testis; and vibrissa. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3). [provided by Alliance of Genome Resources, Apr 2022]

Eif4a3 Products (1)

mRNA Protein Name
NM_138669.1 NP_619610.1 eukaryotic initiation factor 4A-III

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
18480465 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18480465 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18480465 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic initiation factor 4A-III

  • ATP-dependent RNA helicase DDX48

  • ATP-dependent RNA helicase eIF4A-3

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48

  • DEAD box protein 48

  • eIF-4A-III

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101513 eIF4A3-IN-1 Inhibitor 99.96% Unkown
HY-101785 eIF4A3-IN-2 Inhibitor 99.70% Unkown
HY-33838 eIF4A3-IN-8 Control 99.93% Unkown
HY-148452 eIF4A3-IN-18 Inhibitor 99.58% Unkown
HY-148446 eIF4A3-IN-12 Inhibitor 99.70% Unkown
HY-43913 (R)-eIF4A3-IN-2 95.0% Unkown
HY-139872 eIF4A3-IN-4 Inhibitor 99.8% Unkown
HY-145309 eIF4E-IN-3 Inhibitor / Unkown
HY-148443 eIF4A3-IN-9 Inhibitor 99.71% Unkown
HY-148444 eIF4A3-IN-10 Inhibitor 97.87% Unkown
HY-148445 eIF4A3-IN-11 Inhibitor 99.24% Unkown
HY-148447 eIF4A-IN-3 Inhibitor 99.92% Unkown
HY-148448 eIF4A3-IN-14 Inhibitor 99.81% Unkown
HY-148449 eIF4A3-IN-15 Inhibitor / Unkown
HY-148450 eIF4A3-IN-16 Inhibitor 99.96% Unkown
HY-148451 eIF4A3-IN-17 Inhibitor 99.56% Unkown
HY-145359 eIF4A3-IN-5 Inhibitor / Unkown
HY-145360 eIF4A3-IN-6 Inhibitor / Unkown
HY-145361 eIF4A3-IN-7 Inhibitor / Unkown
HY-RS04272 EIF4A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04276 EIF4E3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04279 EIF4EBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04283 EIF4G3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17850 Eif4a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24318 Eif4a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4a3 NCBI NCBI:9775