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Ptprc - protein tyrosine phosphatase, receptor type, C Gene

Also Known as loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19264

Summary

Enables several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine Phosphatase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures, including 3rd branchial arch; alimentary system; cardiovascular system; hemolymphoid system; and placenta. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine Phosphatase receptor type C). [provided by Alliance of Genome Resources, Apr 2022]

Ptprc Products (3)

mRNA	Protein	Name
NM_001111316.2	NP_001104786.2	receptor-type tyrosine-protein phosphatase C isoform 1 precursor
NM_001268286.1	NP_001255215.1	receptor-type tyrosine-protein phosphatase C precursor
NM_011210.4	NP_035340.3	receptor-type tyrosine-protein phosphatase C isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heparan sulfate proteoglycan binding	IDA IDA: Inferred from direct assay	8043862	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	8043862	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8570203	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11201744	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	7743522	MGI
enables protein tyrosine phosphatase activity	IGI IGI: Inferred from genetic interaction	12496963	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12115612	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	8666928	MGI
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	15557316	MGI
acts upstream of B cell proliferation	IMP IMP: Inferred from mutant phenotype	8566034	MGI
involved in B cell proliferation	IMP IMP: Inferred from mutant phenotype	8334701	MGI
acts upstream of or within B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	7499277	MGI
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8692271	MGI
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	9254656	MGI
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	8334701	MGI
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	12902479	MGI
involved in T cell receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12496963	MGI
acts upstream of alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	7751624	MGI
acts upstream of or within defense response to virus	IDA IDA: Inferred from direct assay	17277142	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	8334701	MGI
involved in dephosphorylation	IDA IDA: Inferred from direct assay	11201744	MGI
acts upstream of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	8666928	MGI
acts upstream of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	7807014	MGI
acts upstream of or within heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	7743522	MGI
acts upstream of or within leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	7743522	MGI
involved in natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	15557316	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	15661907	MGI
involved in negative regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	9725213	MGI
involved in negative regulation of cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	11201744	MGI
involved in negative regulation of interleukin-2 production	IGI IGI: Inferred from genetic interaction	15661907	MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	7499277	MGI
acts upstream of or within negative regulation of protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	7499277	MGI
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	10970857	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	8666928	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	7499277	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	8566034	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	15661907	MGI
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway	IGI IGI: Inferred from genetic interaction	18249142	MGI
acts upstream of or within positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	9254656	MGI
involved in positive regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	18249142	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	9254656	MGI
acts upstream of or within positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	8666928	MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	6233370	MGI
acts upstream of or within positive regulation of T cell mediated immunity	IMP IMP: Inferred from mutant phenotype	6233370	MGI
involved in positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	8334701	MGI
acts upstream of or within positive regulation of alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	7751624	MGI
involved in positive regulation of antigen receptor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	8692271	MGI
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	18249142	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	8666928	MGI
acts upstream of or within positive regulation of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	7807014	MGI
acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	8566034	MGI
involved in positive regulation of interleukin-2 production	IGI IGI: Inferred from genetic interaction	15661907	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	9015183	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IGI IGI: Inferred from genetic interaction	18249142	MGI
involved in positive regulation of phagocytosis	IGI IGI: Inferred from genetic interaction	18249142	MGI
involved in positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	18249142	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	8666928	MGI
acts upstream of protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	7499277	MGI
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	9197241	MGI
involved in regulation of T cell receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15661907	MGI
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	10970857	MGI
acts upstream of or within regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	7743522	MGI
involved in regulation of gene expression	IGI IGI: Inferred from genetic interaction	12496963	MGI
acts upstream of or within regulation of humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	9015183	MGI
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	10508267	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell periphery	IDA IDA: Inferred from direct assay	22072979	MGI
located in cell surface	IDA IDA: Inferred from direct assay	15599401	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	61878	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	9197241	MGI
located in membrane microdomain	IDA IDA: Inferred from direct assay	15661907	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15661907	MGI
located in membrane raft	IGI IGI: Inferred from genetic interaction	12496963	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15128768	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
receptor-type tyrosine-protein phosphatase C	leukocyte common antigen lymphocyte antigen 5 lymphocyte common antigen

Recombinant Ptprc Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7884	CD45 Protein, Mouse (HEK293, His)	P06800-4 (Q26-K566)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72914	CD45 Protein, Mouse (sf9)	P06800-4 (R594-S1293)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P72915	CD45 Protein, Mouse (sf9, His-GST)	AAA39458.1 (R453-S1152)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72916	CD45 Protein, Mouse (HEK293, Fc)	NP_035340.3 (Q26-N425)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Ptprc Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86808	CD45 Antibody (YA6501)	WB, IHC-P, IHC-F, FC, ICC/IF, IF-Tissue	Mouse
HY-P86971	CD45 Antibody (YA6664)	IHC-P, FC	Mouse

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11434	PTPRC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18077	Ptprc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24552	Ptprc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990495	Anti-PTPRC/CD45 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptprc	NCBI	NCBI:5788